α-Hydroxymethylation of conjugated nitroalkenes via the Morita-Baylls-Hillman reaction

被引：62
作者：
Rastogi, N
Namboothiri, INN [1 ]
Cojocaru, M
机构：
[1] Indian Inst Technol, Dept Chem, Bombay 400076, Maharashtra, India
[2] Bar Ilan Univ, Dept Chem, IL-52900 Ramat Gan, Israel
来源：
TETRAHEDRON LETTERS | 2004年 / 45卷 / 24期
关键词：
nitroalkenes; Morita-Baylis-Hillman reaction; hydroxymethylation;
D O I：
10.1016/j.tetlet.2004.04.069
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The Morita-Baylis-Hillman reaction (MBHR) of conjugated nitroalkenes has been successfully carried out for the first time. A variety of aromatic and heteroaromatic nitroalkenes react with formaldehyde at room temperature in the presence of stoichiometric amounts of imidazole and catalytic amounts of anthranilic acid in THF providing moderate to good yields of the multifunctional adducts in most of the cases. (C) 2004 Elsevier Ltd. All rights reserved.
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收藏
页码：4745 / 4748
页数：4
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