Mood state and brain electric activity in Ecstasy users

被引：67
作者：
Gamma, A
Frei, E
Lehmann, D
Pascual-Marqui, RD
Hell, D
Vollenweider, FX
机构：
[1] Univ Hosp Psychiat, Res Unit, CH-8029 Zurich, Switzerland
[2] Univ Hosp Psychiat, KEY Inst Brain Mind Res, CH-8029 Zurich, Switzerland
来源：
NEUROREPORT | 2000年 / 11卷 / 01期
关键词：
drug abuse; Ecstasy; EEG; LORETA; MDMA; mood;
D O I：
10.1097/00001756-200001170-00031
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Resting EEG during open and dosed eyes and subsequent mood ratings were obtained from 15 Ecstasy users and 14 Ecstasy-naive controls. Absolute spectral power on the scalp, and the three-dimensional, intracerebral distribution of neuroelectric activity using low resolution brain electromagnetic tomography (LORETA) were computed. LORETA revealed global increases of theta, alpha I and beta2/3 power during eyes open in Ecstasy users, and spectral analyses revealed a right-posterior increase of alpha2 power (confirmed by LORETA) and increased beta band activity during open eyes. Ecstasy users had higher levels of stare depressiveness, emotional excitability and a trend-level increase in state anxiety. The observed differences may be related to regular exposure to Ecstasy or other illicit drugs,or may be pre-existing. NeuroReport 11:157-162 (C) 2000 Lippincott Williams & Wilkins.
引用
收藏
页码：157 / 162
页数：6
相关论文
共 24 条
[1]   PERSISTENT EFFECTS OF (+/-)3,4-METHYLENEDIOXYMETHAMPHETAMINE (MDMA, ECSTASY) ON HUMAN SLEEP [J].
ALLEN, RP ;
MCCANN, UD ;
RICAURTE, GA .
SLEEP, 1993, 16 (06) :560-564
[2]   Alpha EEG activity and subcortical pathology in HIV infection [J].
Baldeweg, T ;
Gruzelier, JH .
INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY, 1997, 26 (1-3) :431-442
[3]   Level of use of 3,4-methylenedioxymethamphetamine (MDMA or Ecstasy) in humans correlates with EEG power and coherence [J].
Dafters, RI ;
Duffy, F ;
O'Donnell, PJ ;
Bouquet, C .
PSYCHOPHARMACOLOGY, 1999, 145 (01) :82-90
[4]  
GAMMA A, 1999, EUR NEUROPSYCHOPH S5, V9, P237
[5]   Nonparametric analysis of statistic images from functional mapping experiments [J].
Holmes, AP ;
Blair, RC ;
Watson, JDG ;
Ford, I .
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1996, 16 (01) :7-22
[6]  
Janke W., 1978, EIGENSCHAFTSWORTERLI
[7]   REFLECTIONS ON THE TOPICS - EEG FREQUENCY BANDS AND REGULATION OF VIGILANCE [J].
KUBICKI, S ;
HERRMANN, WM ;
FICHTE, K ;
FREUND, G .
PHARMAKOPSYCHIATRIE NEURO-PSYCHOPHARMAKOLOGIE, 1979, 12 (02) :237-245
[8]   INTRACEREBRAL DIPOLE SOURCE LOCALIZATION FOR FFT POWER MAPS [J].
LEHMANN, D ;
MICHEL, CM .
ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY, 1990, 76 (03) :271-276
[9]   MDMA (ECSTASY) AND PANIC DISORDER - INDUCTION BY A SINGLE DOSE [J].
MCCANN, UD ;
RICAURTE, GA .
BIOLOGICAL PSYCHIATRY, 1992, 32 (10) :950-953
[10]   Cognitive performance in (±) 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") users:: a controlled study [J].
McCann, UD ;
Mertl, M ;
Eligulashvili, V ;
Ricaurte, GA .
PSYCHOPHARMACOLOGY, 1999, 143 (04) :417-425
123