Increased Serum Phthalates (MEHP, DEHP) and Bisphenol A Concentrations in Children With Autism Spectrum Disorder: The Role of Endocrine Disruptors in Autism Etiopathogenesis

被引：67

作者：

Kardas, Fatih ^{[1
]}

Bayram, Ayse Kacar ^{[2
]}

Demirci, Esra ^{[3
]}

Akin, Leyla ^{[4
]}

Ozmen, Sevgi ^{[3
]}

Kendirci, Mustafa ^{[1
]}

Canpolat, Mehmet ^{[2
]}

Oztop, Didem Behice ^{[2
]}

Narin, Figen ^{[5
]}

Gumus, Hakan ^{[2
]}

Kumandas, Sefer ^{[2
]}

Per, Huseyin ^{[2
]}

机构：

[1] Erciyes Univ, Sch Med, Div Pediat Nutr & Metab, Dept Pediat, TR-38039 Kayseri, Turkey

[2] Erciyes Univ, Sch Med, Div Pediat Neurol, Dept Pediat, TR-38039 Kayseri, Turkey

[3] Erciyes Univ, Sch Med, Dept Child Psychiat, TR-38039 Kayseri, Turkey

[4] Erciyes Univ, Sch Med, Div Pediat Endocrinol, Dept Pediat, TR-38039 Kayseri, Turkey

[5] Erciyes Univ, Sch Med, Dept Biochem, TR-38039 Kayseri, Turkey

来源：

JOURNAL OF CHILD NEUROLOGY | 2016年 / 31卷 / 05期

关键词：

autism spectrum disorders; bisphenol A; children; endocrine disruptors; phthalates; MITOCHONDRIAL DYSFUNCTION; DI-(2-ETHYLHEXYL) PHTHALATE; EXPOSURE; CONTRIBUTES; GENETICS;

D O I：

10.1177/0883073815609150

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The aim of this study was to investigate the relationship between autism spectrum disorders development and exposure to mono-(2-ethylhexyl)-phthalate (MEHP), di-(2-ethylhexyl)-phthalate (DEHP), and bisphenol A (BPA), 1 of the endocrine disruptors, among phthalates. The study included 48 children with autism spectrum disorder (27 boys, 21 girls) and 41 healthy subjects (24 boys, 17 girls) as controls. Serum MEHP, DEHP, and BPA levels were measured by using high-performance liquid chromatography. Children with autism spectrum disorder had significantly increased serum MEHP, DEHP, and BPA concentrations (0.47 +/- 0.14 mu g/ml, 2.70 +/- 0.90 mu g/ml, 1.25 +/- 0.30 ng/ml) compared to healthy control subjects (0.29 +/- 0.05 mu g/ml, 1.62 +/- 0.56 mu g/ml, 0.88 +/- 0.18 ng/ml) respectively (P = .000). The fact that higher serum MEHP, DEHP, and BPA were found levels in the autism spectrum disorder group compared to healthy controls suggests that endocrine disruptors may have a role in the pathogenesis of autism spectrum disorders.

引用

页码：629 / 635

页数：7

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