Synthetic applications of fluorous solid-phase extraction (F-SPE)

被引：287

作者：

Zhang, Wei

Curran, Dennis P.

机构：

[1] Univ Pittsburgh, Appl Res Ctr, Fluorous Technol Inc, Pittsburgh, PA 15238 USA

[2] Univ Pittsburgh, Dept Chem, Pittsburgh, PA 15260 USA

来源：

TETRAHEDRON | 2006年 / 62卷 / 51期

关键词：

fluorous; light fluorous; fluorous silica gel; fluorous solid-phase extraction (F-SPE); reverse F-SPE; plate-to-plate SPE; parallel synthesis; high throughput synthesis; solution-ghase synthesis; separation; reagents; reactants; catalysts; chiral auxiliaries; scavengers; protecting groups; displaceable tags; FluoroFlash((R)); VacMaster((R)); FlashMaster (TM); ex-block; RapidTrace((R)); Whatman((R));

D O I：

10.1016/j.tet.2006.08.051

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthetic applications of fluorous solid-phase extraction (F-SPE) for separation in small molecule synthesis, are discussed. F-SPE systems are consisted of 2 × 12 manifold and employs negative pressure, suitable for SPE cartridges with 2-10g silica gel. The predictability and generic 'fluorous/non-fluorous' nature of F-SPE make it suitable for use in research settings with single compounds. The automated sample loading capability of F-SPE allow it to handle solutions and slurries containing small amounts of solid. F-SPE is used in multiple steps, including tagging, reaction of tagged substrate, and detagging for synthesis of small molecules in oligonucleotide synthesis, peptide synthesis, proteomics, fluorous silica gel, and catalyst/reagent support applications. F-SPE is used for synthesis of fluorous reagents, fluorous reactants, catalysts and scavengers that scavenge undesired reaction components.

引用

页码：11837 / 11865

页数：29

共 133 条

[1]

Barthel-Rosa LP, 1999, COORDIN CHEM REV, V190, P587

[2] Parallel fluorous biphasic synthesis of 3H-quinazolin-4-ones by an Aza-Wittig reaction employing perfluoroalkyl-tagged triphenylphosphine [J].