Urinary excretion of ganciclovir contributes to improvement of adenovirus-associated hemorrhagic cystitis after allogeneic bone marrow transplantation

被引：5
作者：
Nakazawa, Yozo [1 ]
Suzuki, Takefumi [2 ]
Fukuyama, Tetsuhiro [1 ]
Katsuyama, Yoshihiko [3 ]
Tanaka, Miyuki [1 ]
Yanagisawa, Ryu [1 ]
Sakashita, Kazuo [1 ]
Shiohara, Masaaki [1 ]
Koike, Kenichi [1 ]
机构：
[1] Shinshu Univ, Dept Pediat, Sch Med, Matsumoto, Nagano 3908621, Japan
[2] Shinshu Univ Hosp, Dept Lab Med, Matsumoto, Nagano, Japan
[3] Shinshu Univ Hosp, Dept Pharm, Matsumoto, Nagano, Japan
来源：
PEDIATRIC TRANSPLANTATION | 2009年 / 13卷 / 05期
关键词：
adenovirus; ganciclovir; hemorrhagic cystitis; stem-cell transplantation; STEM-CELL TRANSPLANTATION; INFECTION; RECIPIENTS; RIBAVIRIN; CIDOFOVIR; THERAPY; DISEASE; BLOOD;
D O I：
10.1111/j.1399-3046.2008.01027.x
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
A nine-yr-old girl developed AdV-associated HC after bone marrow transplantation. Intravenous GCV markedly reduced urinary AdV DNA loads and improved clinical findings. This appeared to result partly from a high concentration of GCV in urine. GCV may be effective for AdV-induced HC without definitive disseminated infection.
引用
收藏
页码：632 / 635
页数：4
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