The physiological response to cardiovascular 'orphan' G protein-coupled receptor agonists

被引:11
作者
Hare, JM [1 ]
Kass, DA
Stamler, JS
机构
[1] Johns Hopkins Med Inst, Dept Med, Div Cardiol, Baltimore, MD 21287 USA
[2] Duke Univ, Med Ctr, Howard Hughes Med Inst, Durham, NC 27710 USA
[3] Duke Univ, Med Ctr, Dept Med Cardiol, Durham, NC 27710 USA
[4] Duke Univ, Med Ctr, Div Pulm, Durham, NC 27710 USA
关键词
D O I
10.1038/15193
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Cardiac pressor agents typically reduce the amount of blood pumped with each heartbeat. Cardiovascular hemodynamic principles can show whether such a response is physiologic or maladaptive.
引用
收藏
页码:1241 / 1242
页数:2
相关论文
共 14 条
[1]   Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14 [J].
Ames, RS ;
Sarau, HM ;
Chambers, JK ;
Willette, RN ;
Alyar, NV ;
Romanic, AM ;
Louden, CS ;
Foley, JJ ;
Sauermelch, CF ;
Coatney, RW ;
Ao, ZH ;
Disa, J ;
Holmes, SD ;
Stadel, JM ;
Martin, JD ;
Liu, WS ;
Glover, GI ;
Wilson, S ;
McNulty, DE ;
Ellis, CE ;
Elshourbagy, NA ;
Shabon, U ;
Trill, JJ ;
Hay, DWP ;
Ohlstein, EH ;
Bergsma, DJ ;
Douglas, SA .
NATURE, 1999, 401 (6750) :282-286
[2]   Intravenous allopurinol decreases myocardial oxygen consumption and increases mechanical efficiency in dogs with pacing-induced heart failure [J].
Ekelund, UEG ;
Harrison, RW ;
Shokek, O ;
Thakkar, RN ;
Tunin, RS ;
Senzaki, H ;
Kass, DA ;
Marbán, E ;
Hare, JM .
CIRCULATION RESEARCH, 1999, 85 (05) :437-445
[3]   Acute cardiovascular effects of OPC-18790 in patients with congestive heart failure - Time- and dose-dependence analysis based on pressure-volume relations [J].
Feldman, MD ;
Pak, PH ;
Wu, CC ;
Haber, HL ;
Heesch, CM ;
Bergin, JD ;
Powers, ER ;
Cowart, TD ;
Johnson, W ;
Feldman, AM ;
Kass, DA .
CIRCULATION, 1996, 93 (03) :474-483
[4]  
GEORGAKOPOULOS D, 1998, AM J PHYSIOL-HEART C, V274, P1416
[5]   An open-label dose escalation study of the nitric oxide synthase inhibitor, NG-methyI-L-arginine hydrochloride (546C88), in patients with septic shock [J].
Grover, R ;
Zaccardelli, D ;
Colice, G ;
Guntupalli, K ;
Watson, D ;
Vincent, JL .
CRITICAL CARE MEDICINE, 1999, 27 (05) :913-922
[6]  
KASS DA, 1987, CIRCULATION, V76, P1421
[7]   EFFECTIVE ARTERIAL ELASTANCE AS INDEX OF ARTERIAL VASCULAR LOAD IN HUMANS [J].
KELLY, RP ;
TING, CT ;
YANG, TM ;
LIU, CP ;
MAUGHAN, WL ;
CHANG, MS ;
KASS, DA .
CIRCULATION, 1992, 86 (02) :513-521
[8]   CARDIAC AND PERIPHERAL CIRCULATORY RESPONSES TO ANGIOTENSIN AND VASOPRESSIN IN DOGS [J].
LEE, RW ;
STANDAERT, S ;
LANCASTER, LD ;
BUCKLEY, D ;
GOLDMAN, S .
JOURNAL OF CLINICAL INVESTIGATION, 1988, 82 (02) :413-419
[9]   Identification of the natural ligand of an orphan G-protein-coupled receptor involved in the regulation of vasoconstriction [J].
Nothacker, HP ;
Wang, ZW ;
McNeil, AM ;
Saito, Y ;
Merten, S ;
O'Dowd, B ;
Duckles, SP ;
Civelli, O .
NATURE CELL BIOLOGY, 1999, 1 (06) :383-385
[10]   Orexins and orexin receptors: A family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior [J].
Sakurai, T ;
Amemiya, A ;
Ishii, M ;
Matsuzaki, I ;
Chemelli, RM ;
Tanaka, H ;
Williams, SC ;
Richardson, JA ;
Kozlowski, GP ;
Wilson, S ;
Arch, JRS ;
Buckingham, RE ;
Haynes, AC ;
Carr, SA ;
Annan, RS ;
McNulty, DE ;
Liu, WS ;
Terrett, JA ;
Elshourbagy, NA ;
Bergsma, DJ ;
Yanagisawa, M .
CELL, 1998, 92 (04) :573-585