Immune Responses Induced by mRNA Vaccination in Mice, Monkeys and Humans

被引：111
作者：
Cagigi, Alberto [1 ]
Lore, Karin [1 ]
机构：
[1] Karolinska Inst, Karolinska Univ Hosp, Dept Med Solna, Div Immunol & Allergy, S-16164 Solna, Sweden
来源：
VACCINES | 2021年 / 9卷 / 01期
基金：
瑞典研究理事会;
关键词：
mRNA vaccine; dendritic cell; protein translation; type I interferon; Th1; polarization; antibody response; SARS-CoV-2; ANTIGEN-PRESENTING CELLS; T-CELL; IN-VIVO; LIPID NANOPARTICLES; H7N9; INFLUENZA; VACCINES; DELIVERY; PROTECTION; INDUCTION; POTENT;
D O I：
10.3390/vaccines9010061
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
In this concise review, we summarize the concepts behind mRNA vaccination. We discuss the innate and adaptive immune response generated by mRNA vaccines in different animal models and in humans. We give examples of viral infections where mRNA vaccines have shown to induce potent responses and we discuss in more detail the recent SARS-CoV-2 mRNA vaccine trials in humans.
引用
收藏
页码：1 / 14
页数：14
相关论文
共 84 条
  • [61] mRNA vaccine delivery using lipid nanoparticles
    Reichmuth, Andreas M.
    Oberli, Matthias A.
    Jaklenec, Ana
    Langer, Robert
    Blankschtein, Daniel
    [J]. THERAPEUTIC DELIVERY, 2016, 7 (05) : 319 - 334
  • [62] Vaccine Mediated Protection Against Zika Virus-Induced Congenital Disease
    Richner, Justin M.
    Jagger, Brett W.
    Shan, Chao
    Fontes, Camila R.
    Dowd, Kimberly A.
    Cao, Bin
    Himansu, Sunny
    Caine, Elizabeth A.
    Nunes, Bruno T. D.
    Medeiros, Daniele B. A.
    Muruato, Antonio E.
    Foreman, Bryant M.
    Luo, Huanle
    Wang, Tian
    Barrett, Alan D.
    Weaver, Scott C.
    Vasconcelos, Pedro F. C.
    Rossi, Shannan L.
    Ciaramella, Giuseppe
    Mysorekar, Indira U.
    Pierson, Theodore C.
    Shi, Pei-Yong
    Diamond, Michael S.
    [J]. CELL, 2017, 170 (02) : 273 - +
  • [63] Modified mRNA Vaccines Protect against Zika Virus Infection (vol 168, pg 1114, 2017)
    Richner, Justin M.
    Himansu, Sunny
    Dowd, Kimberly A.
    Butler, Scott L.
    Salazar, Vanessa
    Fox, Julie M.
    Julander, Justin G.
    Tang, William W.
    Shresta, Sujan
    Pierson, Theodore C.
    Ciaramella, Giuseppe
    Diamond, Michael S.
    [J]. CELL, 2017, 169 (01) : 176 - 176
  • [64] Immunologic activity and safety of autologous HIV RNA-electroporated dendritic cells in HIV-1 infected patients receiving antiretroviral therapy
    Routy, Jean-Pierre
    Boulassel, Mohamed-Rachid
    Yassine-Diab, Bader
    Nicolette, Charles
    Healey, Don
    Jain, Renu
    Landry, Claire
    Yegorov, Oleg
    Tcherepanova, Irina
    Monesmith, Tamara
    Finke, Lothar
    Sekaly, Rafick-Pierre
    [J]. CLINICAL IMMUNOLOGY, 2010, 134 (02) : 140 - 147
  • [65] COVID-19 vaccine BNT162b1 elicits human antibody and TH1 T cell responses
    Sahin, Ugur
    Muik, Alexander
    Derhovanessian, Evelyna
    Vogler, Isabel
    Kranz, Lena M.
    Vormehr, Mathias
    Baum, Alina
    Pascal, Kristen
    Quandt, Jasmin
    Maurus, Daniel
    Brachtendorf, Sebastian
    Loerks, Verena
    Sikorski, Julian
    Hilker, Rolf
    Becker, Dirk
    Eller, Ann-Kathrin
    Gruetzner, Jan
    Boesler, Carsten
    Rosenbaum, Corinna
    Kuehnle, Marie-Cristine
    Luxemburger, Ulrich
    Kemmer-Brueck, Alexandra
    Langer, David
    Bexon, Martin
    Bolte, Stefanie
    Kariko, Katalin
    Palanche, Tania
    Fischer, Boris
    Schultz, Armin
    Shi, Pei-Yong
    Fontes-Garfias, Camila
    Perez, John L.
    Swanson, Kena A.
    Loschko, Jakob
    Scully, Ingrid L.
    Cutler, Mark
    Kalina, Warren
    Kyratsous, Christos A.
    Cooper, David
    Dormitzer, Philip R.
    Jansen, Kathrin U.
    Tuereci, Oezlem
    [J]. NATURE, 2020, 586 (7830) : 594 - +
  • [66] SANDS H, 1994, MOL PHARMACOL, V45, P932
  • [67] Developing mRNA-vaccine technologies
    Schlake, Thomas
    Thess, Andreas
    Fotin-Mleczek, Mariola
    Kallen, Karl-Josef
    [J]. RNA BIOLOGY, 2012, 9 (11) : 1319 - 1330
  • [68] An mRNA Vaccine Encoding Rabies Virus Glycoprotein Induces Protection against Lethal Infection in Mice and Correlates of Protection in Adult and Newborn Pigs
    Schnee, Margit
    Vogel, Annette B.
    Voss, Daniel
    Petsch, Benjamin
    Baumhof, Patrick
    Kramps, Thomas
    Stitz, Lothar
    [J]. PLOS NEGLECTED TROPICAL DISEASES, 2016, 10 (06):
  • [69] Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19
    Sekine, Takuya
    Perez-Potti, Andre
    Rivera-Ballesteros, Olga
    Stralin, Kristoffer
    Gorin, Jean-Baptiste
    Olsson, Annika
    Llewellyn-Lacey, Sian
    Kamal, Habiba
    Bogdanovic, Gordana
    Muschiol, Sandra
    Wullimann, David J.
    Kammann, Tobias
    Emgard, Johanna
    Parrot, Tiphaine
    Folkesson, Elin
    Rooyackers, Olav
    Eriksson, Lars, I
    Henter, Jan-Inge
    Sonnerborg, Anders
    Allander, Tobias
    Albert, Jan
    Nielsen, Morten
    Klingstrom, Jonas
    Gredmark-Russ, Sara
    Bjorkstrom, Niklas K.
    Sandberg, Johan K.
    Price, David A.
    Ljunggren, Hans-Gustaf
    Aleman, Soo
    Buggert, Marcus
    [J]. CELL, 2020, 183 (01) : 158 - +
  • [70] Recommendations for live viral and bacterial vaccines in immunodeficient patients and their close contacts
    Shearer, William T.
    Fleisher, Thomas A.
    Buckley, Rebecca H.
    Ballas, Zuhair
    Ballow, Mark
    Blaese, R. Michael
    Bonilla, Francisco A.
    Conley, Mary Ellen
    Cunningham-Rundles, Charlotte
    Filipovich, Alexandra H.
    Fuleihan, Ramsay
    Gelfand, Erwin W.
    Hernandez-Trujillo, Vivian
    Holland, Steven M.
    Hong, Richard
    Lederman, Howard M.
    Malech, Harry L.
    Miles, Stephen
    Notarangelo, Luigi D.
    Ochs, Hans D.
    Orange, Jordan S.
    Puck, Jennifer M.
    Routes, John M.
    Stiehm, E. Richard
    Sullivan, Kathleen
    Torgerson, Troy
    Winkelstein, Jerry
    [J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2014, 133 (04) : 961 - 966
123456789