Immune Responses Induced by mRNA Vaccination in Mice, Monkeys and Humans

被引：111
作者：
Cagigi, Alberto [1 ]
Lore, Karin [1 ]
机构：
[1] Karolinska Inst, Karolinska Univ Hosp, Dept Med Solna, Div Immunol & Allergy, S-16164 Solna, Sweden
来源：
VACCINES | 2021年 / 9卷 / 01期
基金：
瑞典研究理事会;
关键词：
mRNA vaccine; dendritic cell; protein translation; type I interferon; Th1; polarization; antibody response; SARS-CoV-2; ANTIGEN-PRESENTING CELLS; T-CELL; IN-VIVO; LIPID NANOPARTICLES; H7N9; INFLUENZA; VACCINES; DELIVERY; PROTECTION; INDUCTION; POTENT;
D O I：
10.3390/vaccines9010061
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
In this concise review, we summarize the concepts behind mRNA vaccination. We discuss the innate and adaptive immune response generated by mRNA vaccines in different animal models and in humans. We give examples of viral infections where mRNA vaccines have shown to induce potent responses and we discuss in more detail the recent SARS-CoV-2 mRNA vaccine trials in humans.
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收藏
页码：1 / 14
页数：14
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