Predictors for Grip Strength Loss in Patients With Chronic Liver Diseases

被引：6

作者：

Nishikawa, Hiroki ^{[1
,2
]}

Yoh, Kazunori ^{[1
]}

Enomoto, Hirayuki ^{[1
]}

Ikeda, Naoto ^{[1
]}

Takashima, Tomoyuki ^{[1
]}

Aizawa, Nobuhiro ^{[1
]}

Nishimura, Takashi ^{[1
]}

Nishiguchi, Shuhei ^{[3
]}

Iijima, Hiroko ^{[1
]}

机构：

[1] Hyogo Coll Med, Div Gastroenterol & Hepatol, Dept Internal Med, 1-1 Mukogawacho, Nishinomiya, Hyogo 6638501, Japan

[2] Hyogo Coll Med, Ctr Clin Res & Educ, Nishinomiya, Hyogo, Japan

[3] Kano Gen Hosp, Osaka, Japan

来源：

IN VIVO | 2021年 / 35卷 / 01期

关键词：

Chronic liver disease; grip strength loss; secular change; liver function; VISCERAL ADIPOSITY; HANDGRIP STRENGTH; WORKING GROUP; SARCOPENIA; GUIDELINES; OUTCOMES;

D O I：

10.21873/invivo.12267

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Background/Aim: To elucidate factors associated with secular changes of grip strength (GS) in patients with chronic liver diseases (CLDs) (n=241, 102 males, median age=63 years, 87 liver cirrhosis cases). Materials and Methods: Delta GS (kg/year) was defined as [GS value (second time) - GS value (first time)]/[time interval between the first and second time]. GS loss (GSL) was defined as Delta GS <0 kg/year. Results: The median Delta GS in patients with non-LC, Child-Pugh A (n=70) and Child-Pugh B (n=17) were 0.3, -0.2 and -1.6 kg/year (overall p<0.0001). In the multivariate analysis of factors linked to the GSL for all cases, extracellular water (ECW) to total body water (TBW) ratio was significant (p=0.0007). In the multivariate analysis in male, no significant factor was found, while in female, ECW to TBW ratio was significant (p=0.0024). Conclusion: Liver functional parameters can be closely linked to the GSL especially in female CLD patients.

引用

页码：363 / 371

页数：9

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