Diltiazem inhibits naloxone-precipitated and spontaneous morphine withdrawal in rats

被引：16
|
作者：
Kishioka, S
Inoue, N
Nishida, S
Fukunaga, Y
Yamamoto, H
机构：
[1] Department of Pharmacology, Wakayama Medical College, Wakayama City, Wakayama 640
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1996年 / 316卷 / 01期
关键词：
diltiazem; naloxone-precipitated withdrawal; morphine withdrawal; spontaneous; corticosterone; plasma; body weight loss; diarrhea; (rat);
D O I：
10.1016/S0014-2999(96)00651-6
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The effects of diltiazem, a Ca2+ channel blocker, on naloxone-precipitated and spontaneous morphine withdrawal were studied in male Sprague-Dawley rats. In naloxone-precipitated withdrawal, body weight loss and plasma corticosterone elevation were dose dependently inhibited by diltiazem injected 4 or 2 and 4 h before naloxone, respectively. Three administrations of diltiazem (17, 11 and 5 h before naloxone) did not reduce the above withdrawal signs. Diarrhea was dose dependently inhibited by all schedule of diltiazem treatments. In spontaneous withdrawal, body weight loss and plasma corticosterone elevation were dose dependently inhibited by two (6 and 12 h) or three (6, 12 and 18 h after the last morphine) treatments with diltiazem at 6-h intervals after the last morphine, but not by a single diltiazem injected 18 h after the last morphine.
引用
收藏
页码：7 / 14
页数：8
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