Recent Advances of Gold Compounds in Anticancer Immunity

被引：63
作者：
Yue, Shuang [1 ]
Luo, Miao [1 ]
Liu, Huiguo [1 ]
Wei, Shuang [1 ]
机构：
[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Resp & Crit Care Med, Wuhan, Peoples R China
来源：
FRONTIERS IN CHEMISTRY | 2020年 / 8卷
基金：
中国国家自然科学基金;
关键词：
gold compounds; innate immunity; adaptive immunity; immunogenic cell death; immune checkpoints;
D O I：
10.3389/fchem.2020.00543
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
In recent years, gold compounds have gained more and more attentions in the design of new metal anticancer drugs. Numerous researches have reported that gold compounds, in addition to their widely studied cytotoxic antitumor effects, also reverse tumor immune escape and directly facilitate the functions of immune cells, leading to enhanced anticancer effects. This review mainly summarizes our current understandings of antitumor effects of gold drugs and their relationships with various aspects of antitumor immunity, including innate immunity, adaptive immunity, immunogenic cell death, and immune checkpoints, as well as their roles in adverse effects. Some recent examples of anticancer gold compounds are highlighted. The property of gold compounds is expected to combine with anticancer immunotherapy, such as immune checkpoint inhibitors, to develop new anticancer therapeutic strategies.
引用
收藏
页数：14
相关论文
共 121 条
  • [1] Antibacterial and antivirulence activities of auranofin against Clostridium difficile
    AbdelKhalek, Ahmed
    Abutaleb, Nader S.
    Mohammad, Haroon
    Seleem, Mohamed N.
    [J]. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2019, 53 (01) : 54 - 62
  • [2] Determinants for Tight and Selective Binding of a Medicinal Dicarbene Gold(I) Complex to a Telomeric DNA G-Quadruplex: a Joint ESI MS and XRD Investigation
    Bazzicalupi, Carla
    Ferraroni, Marta
    Papi, Francesco
    Massai, Lara
    Bertrand, Benoit
    Messori, Luigi
    Gratteri, Paola
    Casini, Angela
    [J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2016, 55 (13) : 4256 - 4259
  • [3] Synthesis and biological evaluation of gold(III) Schiff base complexes for the treatment of hepatocellular carcinoma through attenuating TrxR activity
    Bian, Mianli
    Wang, Xin
    Sun, Ying
    Liu, Wukun
    [J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 193
  • [4] A Gold(I) Complex Containing an Oleanolic Acid Derivative as a Potential Anti-Ovarian-Cancer Agent by Inhibiting TrxR and Activating ROS-Mediated ERS
    Bian, Mianli
    Sun, Ying
    Liu, Yuanhao
    Xu, Zhongren
    Fan, Rong
    Liu, Ziwen
    Liu, Wukun
    [J]. CHEMISTRY-A EUROPEAN JOURNAL, 2020, 26 (31) : 7092 - 7108
  • [5] Targeting the Thioredoxin System as a Strategy for Cancer Therapy
    Bian, Mianli
    Fan, Rong
    Zhao, Sai
    Liu, Wukun
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2019, 62 (16) : 7309 - 7321
  • [6] A novel copper(I) complex induces ER-stress-mediated apoptosis and sensitizes B-acute lymphoblastic leukemia cells to chemotherapeutic agents
    Bortolozzi, Roberta
    Viola, Giampietro
    Porcu, Elena
    Consolaro, Francesca
    Marzano, Cristina
    Pellei, Maura
    Gandin, Valentina
    Basso, Giuseppe
    [J]. ONCOTARGET, 2014, 5 (15) : 5978 - 5991
  • [7] BRAFV600E Co-opts a Conserved MHC Class I Internalization Pathway to Diminish Antigen Presentation and CD8+ T-cell Recognition of Melanoma
    Bradley, Sherille D.
    Chen, Zeming
    Melendez, Brenda
    Talukder, Amjad
    Khalili, Jahan S.
    Rodriguez-Cruz, Tania
    Liu, Shujuan
    Whittington, Mayra
    Deng, Wanleng
    Li, Fenge
    Bernatchez, Chantale
    Radvanyi, Laszlo G.
    Davies, Michael A.
    Hwu, Patrick
    Lizee, Gregory
    [J]. CANCER IMMUNOLOGY RESEARCH, 2015, 3 (06) : 602 - 609
  • [8] Blockade of programmed death-1 Ligands on dendritic cells enhances T cell activation and cytokine production
    Brown, JA
    Dorfman, DM
    Ma, FR
    Sullivan, EL
    Munoz, O
    Wood, CR
    Greenfield, EA
    Freeman, GJ
    [J]. JOURNAL OF IMMUNOLOGY, 2003, 170 (03) : 1257 - 1266
  • [9] Membrane Localized Iridium(III) Complex Induces Endoplasmic Reticulum Stress and Mitochondria-Mediated Apoptosis in Human Cancer Cells
    Cao, Rui
    Jia, Junli
    Ma, Xiaochuan
    Zhou, Ming
    Fei, Hao
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2013, 56 (09) : 3636 - 3644
  • [10] Genome-wide association study of myelosuppression in non-small-cell lung cancer patients with platinum-based chemotherapy
    Cao, S.
    Wang, S.
    Ma, H.
    Tang, S.
    Sun, C.
    Dai, J.
    Wang, C.
    Shu, Y.
    Xu, L.
    Yin, R.
    Song, X.
    Chen, H.
    Han, B.
    Li, Q.
    Wu, J.
    Bai, C.
    Chen, J.
    Jin, G.
    Hu, Z.
    Lu, D.
    Shen, H.
    [J]. PHARMACOGENOMICS JOURNAL, 2016, 16 (01) : 41 - 46
12345678910