Recent Advances of Gold Compounds in Anticancer Immunity

被引：68
作者：
Yue, Shuang [1 ]
Luo, Miao [1 ]
Liu, Huiguo [1 ]
Wei, Shuang [1 ]
机构：
[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Resp & Crit Care Med, Wuhan, Peoples R China
来源：
FRONTIERS IN CHEMISTRY | 2020年 / 8卷
基金：
中国国家自然科学基金;
关键词：
gold compounds; innate immunity; adaptive immunity; immunogenic cell death; immune checkpoints;
D O I：
10.3389/fchem.2020.00543
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
In recent years, gold compounds have gained more and more attentions in the design of new metal anticancer drugs. Numerous researches have reported that gold compounds, in addition to their widely studied cytotoxic antitumor effects, also reverse tumor immune escape and directly facilitate the functions of immune cells, leading to enhanced anticancer effects. This review mainly summarizes our current understandings of antitumor effects of gold drugs and their relationships with various aspects of antitumor immunity, including innate immunity, adaptive immunity, immunogenic cell death, and immune checkpoints, as well as their roles in adverse effects. Some recent examples of anticancer gold compounds are highlighted. The property of gold compounds is expected to combine with anticancer immunotherapy, such as immune checkpoint inhibitors, to develop new anticancer therapeutic strategies.
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页数：14
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