Photoredox-Catalyzed Tandem Radical Cyclization of N-Arylacrylamides: General Methods To Construct Fluorinated 3,3-Disubstituted 2-Oxindoles Using Fluoroalkylsulfonyl Chlorides

被引：303

作者：

Tang, Xiao-Jun ^{[1
]}

Thomoson, Charles S. ^{[1
]}

Dolbier, William R., Jr. ^{[1
]}

机构：

[1] Univ Florida, Dept Chem, Gainesville, FL 32611 USA

来源：

ORGANIC LETTERS | 2014年 / 16卷 / 17期

关键词：

ACTIVATED ALKENES; ROOM-TEMPERATURE; SODIUM TRIFLUOROMETHANESULFINATE; ENANTIOSELECTIVE SYNTHESIS; CF3-CONTAINING OXINDOLES; RUTHENIUM(II) COMPLEX; MEDICINAL CHEMISTRY; TRIFLUOROMETHYLATION; FUNCTIONALIZATION; CASCADE;

D O I：

10.1021/ol502163f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Fluorinated radicals were generated from RfSO2Cl by photoredox catalysis under mild conditions, where R-f = n-C4F9, CF3, CF2H, CH2F, CH2CF3, and CF2CO2Me. This method provided a general way to construct fluorinated 2-oxindoles from reaction with N-arylacrylamides via a proposed tandem radical cyclization process.

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收藏

页码：4594 / 4597

页数：4

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