Update on Muller glia regenerative potential for retinal repair

被引：21

作者：

Garcia-Garcia, Diana ^{[1
]}

Locker, Morgane ^{[1
]}

Perron, Muriel ^{[1
]}

机构：

[1] Univ Paris Saclay, Inst Neurosci Paris Saclay, Retina France, CNRS, Orsay, France

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2020年 / 64卷

关键词：

MICRORNA EXPRESSION; ZEBRAFISH RETINA; NEURAL RETINA; STEM-CELLS; PROLIFERATION; DEDIFFERENTIATION; SUFFICIENT; DEGENERATION; MICROGLIA; NEURONS;

D O I：

10.1016/j.gde.2020.05.025

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Retinal regeneration efficiency from Muller glia varies tremendously among vertebrate species, being extremely limited in mammals. Efforts towards the identification of molecular mechanisms underlying Muller cell proliferative and neurogenic potential should help finding strategies to awake them and ensure regeneration in mammals. We provide here an update on the most recent and original progresses made in the field. These include remarkable discoveries regarding (i) unprecedented cross-species comparison of Muller cell transcriptome using single-cell technologies, (ii) the identification of new strategies to promote both the proliferative and the neurogenic potential of mammalian Muller cells, (iii) the role of the epigenome in regulating Muller glia plasticity, (iv) miRNA-based regulatory mechanisms of Muller cell response to injury, and (v) the influence of inflammatory signals on the regenerative process.

引用

页码：52 / 59

页数：8

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