Hypothalamic perineuronal net assembly is required for sustained diabetes remission induced by fibroblast growth factor 1 in rats

被引：39

作者：

Alonge, Kimberly M. ^{[1
]}

Mirzadeh, Zaman ^{[2
]}

Scarlett, Jarrad M. ^{[1
,3
]}

Logsdon, Aric F. ^{[4
,5
,6
]}

Brown, Jenny M. ^{[1
]}

Cabrales, Elaine ^{[2
]}

Chan, Christina K. ^{[7
]}

Kaiyala, Karl J. ^{[8
]}

Bentsen, Marie A. ^{[1
,9
]}

Banks, William A. ^{[4
,5
,6
]}

Guttman, Miklos ^{[10
]}

Wight, Thomas N. ^{[7
]}

Morton, Gregory J. ^{[1
]}

Schwartz, Michael W. ^{[1
]}

机构：

[1] Univ Washington, Med Diabet Inst, Seattle, WA 98195 USA

[2] Barrow Neurol Inst, Dept Neurosurg, Phoenix, AZ 85013 USA

[3] Seattle Childrens Hosp, Dept Pediat Gastroenterol & Hepatol, Seattle, WA USA

[4] Univ Washington, Dept Geriatr Res Educ, Vet Affairs Puget Sound Hlth Care Syst, Seattle, WA 98195 USA

[5] Univ Washington, Clin Ctr GRECC, Vet Affairs Puget Sound Hlth Care Syst, Seattle, WA 98195 USA

[6] Univ Washington, Dept Med, Div Gerontol & Geriatr Med, Seattle, WA USA

[7] Benaroya Res Inst, Matrix Biol Program, Seattle, WA USA

[8] Univ Washington, Sch Dent, Dept Oral Hlth Sci, Seattle, WA 98195 USA

[9] Univ Copenhagen, Fac Hlth & Med Sci, Novo Nordisk Fdn Ctr Basic Metab Res, Copenhagen, Denmark

[10] Univ Washington, Dept Med Chem, Seattle, WA 98195 USA

来源：

NATURE METABOLISM | 2020年 / 2卷 / 10期

关键词：

CHONDROITIN SULFATE D; LIQUID-CHROMATOGRAPHY; EXTRACELLULAR-MATRIX; PREFRONTAL CORTEX; AXON-GROWTH; NEURONS; LEPTIN; PLASTICITY; INJECTION; CARTILAGE;

D O I：

10.1038/s42255-020-00275-6

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We recently showed that perineuronal nets (PNNs) enmesh glucoregulatory neurons in the arcuate nucleus (Arc) of the mediobasal hypothalamus (MBH)(1), but whether these PNNs play a role in either the pathogenesis of type 2 diabetes (T2D) or its treatment remains unclear. Here we show that PNN abundance within the Arc is markedly reduced in the Zucker diabetic fatty (ZDF) rat model of T2D, compared with normoglycaemic rats, correlating with altered PNN-associated sulfation patterns of chondroitin sulfate glycosaminoglycans in the MBH. Each of these PNN-associated changes is reversed following a single intracerebroventricular (icv) injection of fibroblast growth factor 1 (FGF1) at a dose that induces sustained diabetes remission in male ZDF rats. Combined with previous work localizing this FGF1 effect to the Arc area(2-4), our finding that enzymatic digestion of Arc PNNs markedly shortens the duration of diabetes remission following icv FGF1 injection in these animals identifies these extracellular matrix structures as previously unrecognized participants in the mechanism underlying diabetes remission induced by the central action of FGF1.

引用

页码：1025 / +

页数：11

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