Correcting aberrant kinetochore microtubule attachments: an Aurora B-centric view

被引：110

作者：

Kelly, Alexander E. ^{[1
]}

Funabiki, Hironori ^{[1
]}

机构：

[1] Rockefeller Univ, Lab Chromosome & Cell Biol, New York, NY 10065 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2009年 / 21卷 / 01期

关键词：

CHROMOSOME-SPINDLE ATTACHMENTS; DYNAMIC RELOCALIZATION; CHECKPOINT FUNCTION; INNER CENTROMERE; MITOTIC SPINDLE; KINASE-ACTIVITY; REGULATES MCAK; CELL-DIVISION; BUDDING YEAST; HISTONE H3;

D O I：

10.1016/j.ceb.2009.01.004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The directed movement of chromosomes during mitosis and meiosis relies on microtubule-mediated connections between spindle poles and kinetochores assembled on chromosomes. The molecular basis for the dynamic interaction between microtubules and kinetochores is just beginning to be unveiled. Here, focusing on the mitotic centromere kinase Aurora B, we review our current understanding of the signaling pathways that correct erroneous microtubule attachment at kinetochores. We evaluate several potential models that may explain how maloriented attachments are recognized and processed by the Aurora B pathway.

引用

页码：51 / 58

页数：8

共 64 条

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