Calcium Signaling in Xenopus oocyte

被引：6

作者：

Marin, Matthieu ^{[1
]}

机构：

[1] Univ Lille 1, Lab Regulat Signaux Div, EA 4479, IFR 147, F-59655 Villeneuve Dascq, France

来源：

CALCIUM SIGNALING | 2012年 / 740卷

关键词：

Xenopus laevis; Oocyte; Calcium signaling; Maturation; pH; Electrophysiology; Double electrode; Microinjection; Calcium-activated chloride channels; Cell cycle; Meiosis; Germinal vesicle break down; G2/M transition; MPF; Calcium entry; Calcium release; Store Operated Calcium Entry; IP3; Fertilization; MATURATION-PROMOTING FACTOR; GERMINAL VESICLE BREAKDOWN; ACTIVATED PROTEIN-KINASE; SEA-URCHIN EGGS; INOSITOL TRISPHOSPHATE; MEIOTIC MATURATION; INTRACELLULAR PH; CELL-CYCLE; LAEVIS OOCYTES; ION CHANNELS;

D O I：

10.1007/978-94-007-2888-2_49

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Knowledge about calcium signaling had increased thanks to the development and manipulation of various cell models. Among all of these prototypes, Xenopus laevis oocyte appears to be one of the most relevant. The understanding of the role of calcium during oocyte oogenesis, maturation and fertilization is facilitated by the big size of the cell but also by using imaging and electrophysiological approaches. So, this chapter presents how recordings of calcium-activated chloride channels and Store-Operated Calcium Channels activities lead to demonstrate the implication of the MPF in the uncoupling between intracellular calcium releasing and capacitative calcium entry. Moreover, it will help us to understand the several reorganizations happening consequently to the pH variations of maturation or just at the moment of fertilization.

引用

页码：1073 / 1094

页数：22

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[1] Fast and slow gating are inherent properties of the pore module of the K+ channel Kcv [J].