Electroencephalogram and somatosensory evoked potential evaluation for good and poor neurological prognosis after cardiac arrest: a prospective multicenter cohort trial (ProNeCA)

被引:9
作者
Scarpino, Maenia [1 ]
Carrai, Riccardo [1 ,2 ]
Lolli, Francesco [3 ]
Lanzo, Giovanni [2 ]
Spalletti, Maddalena [2 ]
Audenino, Daniela [4 ]
Callegarin, Claudio [5 ]
Celani, Maria Grazia [6 ]
Lombardi, Maria [7 ]
Marrelli, Alfonso [8 ]
Mecarelli, Oriano [9 ]
Minardi, Chiara [10 ]
Minicucci, Fabio [11 ]
Motti, Luisa [12 ]
Politini, Lucia [13 ]
Valzania, Franco [14 ]
Vitelli, Eugenio [15 ]
Peris, Adriano [16 ]
Amantini, Aldo [1 ,2 ]
Grippo, Antonello [1 ,2 ]
机构
[1] IRCCS Fdn Don Carlo Gnocchi, Florence, Italy
[2] AOU Careggi, Dipartimento Neuromuscoloscheletr & Organi Senso, SODc Neurofisiopatol, Florence, Italy
[3] Univ Firenze, Dipartimento Sci Biomed Sperimentali & Clin, Florence, Italy
[4] Osped Galliera, SC Neurol, Genoa, Italy
[5] Osped Santa Maria Croci, UO Neurol & Neurofisiopatol, Ravenna, Italy
[6] Osped Santa Maria Misericordia, UO Neurofisiopatol, Perugia, Italy
[7] Osped San Giuseppe, UO Neurol, Empoli, Italy
[8] Osped San Salvatore, UOC Neurofisiopatol, Laquila, Italy
[9] Univ Roma La Sapienza, Policlin Umberto Primo, UOC Neurofisiopatol, Rome, Italy
[10] Osped Bufalini, UO Neurol, Cesena, Italy
[11] Osped San Raffaele IRCCS, UO Neurofisiopatol, Milan, Italy
[12] UO Neurofisiopatol Arcispedale, Santa Maria Nuova, Reggio Nellemil, Italy
[13] Osped Civile, Legnano, Italy
[14] Osp Civile Baggiovara, Neurofisiopatol Intervent, Modena, Italy
[15] Osped Maggiore Lodi, Lodi, Italy
[16] AOU Careggi, Dipartimento Neuromuscolo Scheletr & Organi Senso, SODc Cure Intens Trauma & Supporti Extracorporei, Florence, Italy
关键词
cardiac arrest; EEG; hypoxic ischemic encephalopathy; multicenter study; multimodal prognosis; neurological outcome; neurophysiological tests; ProNeCA; prospective study; SEPs; ELEVATION MYOCARDIAL-INFARCTION; EUROPEAN RESUSCITATION COUNCIL; CARDIOPULMONARY-RESUSCITATION; THERAPEUTIC HYPOTHERMIA; CLINICAL NEUROPHYSIOLOGY; CONTINUOUS EEG; TASK-FORCE; PREDICTION; MIDAZOLAM; ASSOCIATION;
D O I
10.2217/fnl-2018-0036
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Aim: Hypoxic-ischemic-encephalopathy is a severe and frequent neurological complication of successful cardiopulmonary-resuscitation after cardiac arrest. Prognosticating neurological outcomes in patients with hypoxic-ischemic-encephalopathy is challenging and recent guidelines suggest a multimodal approach. Only few studies have analyzed the prognostic power of the association between instrumental tests and, in addition, most of them were monocentric, retrospective and evaluating only poor outcome. Methods/design: We designed a multicenter prospective cohort study to assessing the prognostic power of the association of electroencephalogram and somatosensory evoked potentials for the prediction of both poor and good neurological outcomes at different times after cardiac arrest. Discussion: The results of our study will provide a high level of evidence for the use of neurophysiological evaluation in the current clinical practice.
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页数:10
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