Recent developments in C-H functionalization via C-H bond activation using ball milling and transition-metal catalysts

The inert C-H bond functionalization via bond activation in the presence of transition metals using ball milling is reviewed. The use of several transition metals, such as Pd, Rh, Ru, Co, and Ir are covered in this review for a variety of important functionalizations, including halogenation, amidation, alkynylation, and dehydrogenative coupling, among others. These reactions are performed under mild conditions, usually without any solvent, and in relatively short reaction times. [GRAPHICS] .