Twisting and Ironing: Doxorubicin Cardiotoxicity by Mitochondrial DNA Damage

被引：52

作者：

Nitiss, Karin C. ^{[1
,2
]}

Nitiss, John L. ^{[1
,2
]}

机构：

[1] UIC Coll Med, Dept Biomed Sci, Rockford, IL USA

[2] UIC Coll Pharm, Dept Biopharmaceut Sci, Rockford, IL USA

来源：

CLINICAL CANCER RESEARCH | 2014年 / 20卷 / 18期

关键词：

TOPOISOMERASE-I;

D O I：

10.1158/1078-0432.CCR-14-0821

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Anthracyclines are active clinical agents that have multiple mechanisms of cytotoxicity. Cardiotoxicity by anthracyclines limits the therapeutic potential of these agents, but mechanisms leading to cardiotoxicity remain controversial. Transgenic mice that lack mitochondrial topoisomerase I are hypersensitive to doxorubicin cardiotoxicity, providing support for cardiotoxicity arising from damage of mitochondrial DNA. (C)2014 AACR.

引用

页码：4737 / 4739

页数：3

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