Endothelial Shear Stress and Blood Viscosity in Peripheral Arterial Disease

被引：64

作者：

Cho, Young I. ^{[1
]}

Cho, Daniel J. ^{[2
]}

Rosenson, Robert S. ^{[3
]}

机构：

[1] Drexel Univ, Dept Mech Eng & Mech, Philadelphia, PA 19104 USA

[2] Rheovector LLC, Camden, NJ 08103 USA

[3] Icahn Sch Med Mt Sinai, New York, NY 10029 USA

来源：

CURRENT ATHEROSCLEROSIS REPORTS | 2014年 / 16卷 / 04期

关键词：

Endothelial shear stress; Blood viscosity; Peripheral arterial disease; Tortuosity; Curvature; Intermittent claudication; Critical limb ischemia; Hemodilution; Cilostazol; Pentoxifylline; Chylomicrons; VLDL; LDL; Hyperviscosity; Pain-free walking distance; CARDIOVASCULAR RISK-FACTORS; HUMAN CAROTID BIFURCATION; HIGH-DENSITY-LIPOPROTEIN; INTERMITTENT CLAUDICATION; WALL SHEAR; FEMORAL-ARTERY; INTRAVASCULAR ULTRASOUND; BIOCHEMICAL FINDINGS; WALKING DISTANCE; PLASMA VISCOSITY;

D O I：

10.1007/s11883-014-0404-6

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

This review examines the emerging role of endothelial shear stress (ESS) and blood viscosity on the initiation and progression of atherosclerosis in peripheral arterial disease. Among the variables determining ESS, blood viscosity has to date been the most overlooked by clinical researchers. Blood viscosity is a laboratory assessment that is minimally invasive and modifiable using pharmacologic therapy as well as by hemodilution. Monitoring and controlling blood viscosity not only modulates ESS, but also reduces peripheral vascular resistance and increases blood flow to the lower extremities.

引用

页数：10

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