Shouldn't we care about the-biology of benign tumours?

被引：37

作者：

Marino-Enriquez, Adrian ^{[1
]}

Fletcher, Christopher D. M. ^{[1
]}

机构：

[1] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Pathol, Boston, MA 02115 USA

来源：

NATURE REVIEWS CANCER | 2014年 / 14卷 / 11期

关键词：

METASTASIS;

D O I：

10.1038/nrc3845

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

While focusing on malignant tumours seems medically reasonable, from a biological perspective, benign and malignant tumours provide complementary and perhaps equally relevant perspectives on the mechanisms of tumour invasion and metastasis. However, the biology of benign neoplasms is rarely studied.

引用

收藏

页码：701 / 702

页数：2

相关论文

共 11 条

[1] Metastasis genes: A progression puzzle [J].

Bernards, R ;

Weinberg, RA .

NATURE, 2002, 418 (6900) :823-823

[2] BrafV600E cooperates with Pten loss to induce metastatic melanoma [J].

Dankort, David ;

Curley, David P. ;

Cartlidge, Robert A. ;

Nelson, Betsy ;

Karnezis, Anthony N. ;

Damsky, William E., Jr. ;

You, Mingjian J. ;

DePinho, Ronald A. ;

McMahon, Martin ;

Bosenberg, Marcus .

NATURE GENETICS, 2009, 41 (05) :544-552

[3] Metastasizing "Benign" Cutaneous Fibrous Histiocytoma A Clinicopathologic Analysis of 16 Cases [J].

Doyle, Leona A. ;

Fletcher, Christopher D. M. .

AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2013, 37 (04) :484-495

[4] Tumors as Organs: Complex Tissues that Interface with the Entire Organism [J].

Egeblad, Mikala ;

Nakasone, Elizabeth S. ;

Werb, Zena .

DEVELOPMENTAL CELL, 2010, 18 (06) :884-901

[5] A GENETIC MODEL FOR COLORECTAL TUMORIGENESIS [J].

FEARON, ER ;

VOGELSTEIN, B .

CELL, 1990, 61 (05) :759-767

[6] Hallmarks of Cancer: The Next Generation [J].

Hanahan, Douglas ;

Weinberg, Robert A. .

CELL, 2011, 144 (05) :646-674

[7] Characterization of Uterine Leiomyomas by Whole-Genome Sequencing [J].

Mehine, Miika ;

Kaasinen, Eevi ;

Makinen, Netta ;

Katainen, Riku ;

Kampjarvi, Kati ;

Pitkanen, Esa ;

Heinonen, Hanna-Riikka ;

Butzow, Ralf ;

Kilpivaara, Outi ;

Kuosmanen, Anna ;

Ristolainen, Heikki ;

Gentile, Massimiliano ;

Sjoberg, Jari ;

Vahteristo, Pia ;

Aaltonen, Lauri A. .

NEW ENGLAND JOURNAL OF MEDICINE, 2013, 369 (01) :43-53

[8] Genetic determinants of cancer metastasis [J].

Nguyen, Don X. ;

Massague, Joan .

NATURE REVIEWS GENETICS, 2007, 8 (05) :341-352

[9] Unravelling the complexity of metastasis - molecular understanding and targeted therapies [J].

Sethi, Nilay ;

Kang, Yibin .

NATURE REVIEWS CANCER, 2011, 11 (10) :735-748

[10] Cancer Genome Landscapes [J].

Vogelstein, Bert ;

Papadopoulos, Nickolas ;

Velculescu, Victor E. ;

Zhou, Shibin ;

Diaz, Luis A., Jr. ;

Kinzler, Kenneth W. .

SCIENCE, 2013, 339 (6127) :1546-1558