Shouldn't we care about the-biology of benign tumours?

被引:37
作者
Marino-Enriquez, Adrian [1 ]
Fletcher, Christopher D. M. [1 ]
机构
[1] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Pathol, Boston, MA 02115 USA
关键词
METASTASIS;
D O I
10.1038/nrc3845
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
While focusing on malignant tumours seems medically reasonable, from a biological perspective, benign and malignant tumours provide complementary and perhaps equally relevant perspectives on the mechanisms of tumour invasion and metastasis. However, the biology of benign neoplasms is rarely studied.
引用
收藏
页码:701 / 702
页数:2
相关论文
共 11 条
  • [1] Metastasis genes: A progression puzzle
    Bernards, R
    Weinberg, RA
    [J]. NATURE, 2002, 418 (6900) : 823 - 823
  • [2] BrafV600E cooperates with Pten loss to induce metastatic melanoma
    Dankort, David
    Curley, David P.
    Cartlidge, Robert A.
    Nelson, Betsy
    Karnezis, Anthony N.
    Damsky, William E., Jr.
    You, Mingjian J.
    DePinho, Ronald A.
    McMahon, Martin
    Bosenberg, Marcus
    [J]. NATURE GENETICS, 2009, 41 (05) : 544 - 552
  • [3] Metastasizing "Benign" Cutaneous Fibrous Histiocytoma A Clinicopathologic Analysis of 16 Cases
    Doyle, Leona A.
    Fletcher, Christopher D. M.
    [J]. AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2013, 37 (04) : 484 - 495
  • [4] Tumors as Organs: Complex Tissues that Interface with the Entire Organism
    Egeblad, Mikala
    Nakasone, Elizabeth S.
    Werb, Zena
    [J]. DEVELOPMENTAL CELL, 2010, 18 (06) : 884 - 901
  • [5] A GENETIC MODEL FOR COLORECTAL TUMORIGENESIS
    FEARON, ER
    VOGELSTEIN, B
    [J]. CELL, 1990, 61 (05) : 759 - 767
  • [6] Hallmarks of Cancer: The Next Generation
    Hanahan, Douglas
    Weinberg, Robert A.
    [J]. CELL, 2011, 144 (05) : 646 - 674
  • [7] Characterization of Uterine Leiomyomas by Whole-Genome Sequencing
    Mehine, Miika
    Kaasinen, Eevi
    Makinen, Netta
    Katainen, Riku
    Kampjarvi, Kati
    Pitkanen, Esa
    Heinonen, Hanna-Riikka
    Butzow, Ralf
    Kilpivaara, Outi
    Kuosmanen, Anna
    Ristolainen, Heikki
    Gentile, Massimiliano
    Sjoberg, Jari
    Vahteristo, Pia
    Aaltonen, Lauri A.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2013, 369 (01) : 43 - 53
  • [8] Genetic determinants of cancer metastasis
    Nguyen, Don X.
    Massague, Joan
    [J]. NATURE REVIEWS GENETICS, 2007, 8 (05) : 341 - 352
  • [9] Unravelling the complexity of metastasis - molecular understanding and targeted therapies
    Sethi, Nilay
    Kang, Yibin
    [J]. NATURE REVIEWS CANCER, 2011, 11 (10) : 735 - 748
  • [10] Cancer Genome Landscapes
    Vogelstein, Bert
    Papadopoulos, Nickolas
    Velculescu, Victor E.
    Zhou, Shibin
    Diaz, Luis A., Jr.
    Kinzler, Kenneth W.
    [J]. SCIENCE, 2013, 339 (6127) : 1546 - 1558