Stereotactic body radiotherapy (SBRT) for multiple pulmonary oligometastases: Analysis of number and timing of repeat SBRT as impact factors on treatment safety and efficacy

被引：37

作者：

Klement, R. J. ^{[1
]}

Hoerner-Rieber, J. ^{[2
,3
]}

Adebahr, S. ^{[4
,5
,6
]}

Andratschke, N. ^{[7
]}

Blanck, O. ^{[8
]}

Boda-Heggemann, J. ^{[9
]}

Duma, M. ^{[10
]}

Eble, M. J. ^{[11
]}

Eich, H. C. ^{[12
]}

Flentje, M. ^{[13
]}

Gerum, S. ^{[14
]}

Hass, P. ^{[15
]}

Henkenberens, C. ^{[16
]}

Hildebrandt, G. ^{[17
]}

Imhoff, D. ^{[18
]}

Kahl, K. H. ^{[19
]}

Klass, N. D. ^{[20
]}

Krempien, R. ^{[21
]}

Lohaus, F. ^{[5
,6
,22
,23
,24
]}

Petersen, C. ^{[25
]}

Schrade, E. ^{[26
]}

Wendt, T. G. ^{[27
]}

Wittig, A. ^{[28
]}

Guckenberger, M. ^{[7
]}

机构：

[1] Leopoldina Hosp, Dept Radiat Oncol, Schweinfurt, Germany

[2] Univ Hosp Heidelberg, Dept Radiat Oncol, Heidelberg, Germany

[3] HIRO, NCRO, Heidelberg, Germany

[4] Univ Freiburg, Dept Radiat Oncol, Med Ctr, Fac Med, Freiburg, Germany

[5] German Canc Res Ctr, Heidelberg, Germany

[6] German Canc Consortium DKTK, Heidelberg, Germany

[7] Univ Zurich, Dept Radiat Oncol, Univ Zurich Hosp, Zurich, Switzerland

[8] UKSH Univ Klinikum Schleswig Holstein, Dept Radiat Oncol, Kiel, Germany

[9] Heidelberg Univ, Dept Radiat Oncol, Univ Med Ctr Mannheim, Heidelberg, Germany

[10] Tech Univ Munich, Dept Radiat Oncol, Munich, Germany

[11] Univ Hosp Aachen, Dept Radiat Oncol, Aachen, Germany

[12] Univ Hosp Munster, Dept Radiat Oncol, Munster, Germany

[13] Univ Hosp Wuerzburg, Dept Radiat Oncol, Wurzburg, Germany

[14] Ludwig Maximilians Univ Munchen, Dept Radiat Oncol, Munich, Germany

[15] Univ Hosp Magdeburg, Dept Radiat Oncol, Magdeburg, Germany

[16] Med Sch Hannover, Dept Radiotherapy & Special Oncol, Hannover, Germany

[17] Univ Rostock, Dept Radiat Oncol, Rostock, Germany

[18] Univ Hosp Frankfurt, Dept Radiat Oncol, Frankfurt, Germany

[19] Hosp Augsburg, Dept Radiat Oncol, Augsburg, Germany

[20] Bern Univ Hosp, Dept Radiat Oncol, Bern, Switzerland

[21] Helios Klinikum Berlin Buch, Dept Radiat Oncol, Berlin, Germany

[22] Tech Univ Dresden, Dept Radiat Oncol, Fac Med, Dresden, Germany

[23] Tech Univ Dresden, Univ Hosp Carl Gustav Carus, Dresden, Germany

[24] OncoRay Natl Ctr Radiat Res Oncol NCRO, Dresden, Germany

[25] Univ Hosp Hamburg, Dept Radiat Oncol, Hamburg, Germany

[26] Hosp Heidenheim, Dept Radiat Oncol, Heidenheim, Germany

[27] Univ Hosp Jena, Dept Radiat Oncol, Jena, Germany

[28] Philipps Univ Marburg, Dept Radiotherapy & Radiat Oncol, Univ Hosp Giessen & Marburg, Marburg, Germany

来源：

RADIOTHERAPY AND ONCOLOGY | 2018年 / 127卷 / 02期

关键词：

Oligometastasis; Stereotactic body radiotherapy; Repeat SBRT; Oligorecurrence; RADIATION-THERAPY; COLORECTAL-CANCER; LUNG METASTASES; PHASE-II; TUMORS; TRIAL; REIRRADIATION; RECURRENCE;

D O I：

10.1016/j.radonc.2018.02.016

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Stereotactic body radiotherapy (SBRT) for oligometastatic disease is characterized by an excellent safety profile; however, experiences are mostly based on treatment of one single metastasis. It was the aim of this study to evaluate safety and efficacy of SBRT for multiple pulmonary metastases. Patients and methods: This study is based on a retrospective database of the DEGRO stereotactic working group, consisting of 637 patients with 858 treatments. Cox regression and logistic regression were used to analyze the association between the number of SBRT treatments or the number and the timing of repeat SBRT courses with overall survival (OS) and the risk of early death. Results: Out of 637 patients, 145 patients were treated for multiple pulmonary metastases; 88 patients received all SBRT treatments within one month whereas 57 patients were treated with repeat SBRT separated by at least one month. Median OS for the total patient population was 23.5 months and OS was not significantly influenced by the overall number of SBRT treatments or the number and timing of repeat SBRT courses. The risk of early death within 3 and 6 months was not increased in patients treated with multiple SBRT treatments, and no grade 4 or grade 5 toxicity was observed in these patients. Conclusions: In appropriately selected patients, synchronous SBRT for multiple pulmonary oligometastases and repeat SBRT may have a comparable safety and efficacy profile compared to SBRT for one single oligometastasis. (C) 2018 Elsevier B.V. All rights reserved.

引用

页码：246 / 252

页数：7

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