The scavenger receptor MARCO is required for lung defense against pneumococcal pneumonia and inhaled particles

被引:264
作者
Arredouani, M
Yang, ZP
Ning, YY
Qin, GZ
Soininen, R
Tryggvason, K
Kobzik, L
机构
[1] Harvard Univ, Sch Publ Hlth, Physiol Program, Boston, MA 02115 USA
[2] Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA
[3] Univ Oulu, Bioctr, Dept Med Biochem & Mol Biol, Oulu 90014, Finland
[4] Karolinska Inst, Dept Med Biochem & Biophys, S-17177 Stockholm, Sweden
关键词
macrophage; phagocytosis; environment; innate immunity;
D O I
10.1084/jem.20040731
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Alveolar macrophages (AMs) express the class A scavenger receptor macrophage receptor with collagenous structure (MARCO), but its role in vivo in lung defense against bacteria and environmental particles has not been studied. We used MARCO-deficient mice to directly test the in vivo role of AM MARCO in innate defense against pneumococcal infection and environmental particles. In a murine model of pneumococcal pneumonia, MARCO(-/-) mice displayed an impaired ability to clear bacteria from the lungs, increased pulmonary inflammation and cytokine release, and diminished survival. In vitro binding of Streptococcus pneumoniae and in vivo uptake of unopsonized particles by MARCO(-/-) AMs were dramatically impaired. MARCO(-/-) mice treated with the "inert" environmental particle TiO2 showed enhanced inflammation and chemokine expression, indicating that MARCO-mediated clearance of inert particles by AMs prevents inflammatory responses otherwise initiated by other lung cells. Our findings point to an important role of MARCO in mounting an efficient and appropriately regulated innate immune response against inhaled particles and airborne pathogens.
引用
收藏
页码:267 / 272
页数:6
相关论文
共 29 条
[1]   Alveolar macrophage apoptosis contributes to pneumococcal clearance in a resolving model of pulmonary infection [J].
Dockrell, DH ;
Marriott, HM ;
Prince, LR ;
Ridger, VC ;
Ince, PG ;
Hellewell, PG ;
Whyte, MKB .
JOURNAL OF IMMUNOLOGY, 2003, 171 (10) :5380-5388
[2]   MACROPHAGE INFLAMMATORY PROTEIN-1 AND PROTEIN-2 - EXPRESSION BY RAT ALVEOLAR MACROPHAGES, FIBROBLASTS, AND EPITHELIAL-CELLS AND IN RAT LUNG AFTER MINERAL DUST EXPOSURE [J].
DRISCOLL, KE ;
HASSENBEIN, DG ;
CARTER, J ;
POYNTER, J ;
ASQUITH, TN ;
GRANT, RA ;
WHITTEN, J ;
PURDON, MP ;
TAKIGIKU, R .
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 1993, 8 (03) :311-318
[3]   THE TYPE-I MACROPHAGE SCAVENGER RECEPTOR BINDS TO GRAM-POSITIVE BACTERIA AND RECOGNIZES LIPOTEICHOIC ACID [J].
DUNNE, DW ;
RESNICK, D ;
GREENBERG, J ;
KRIEGER, M ;
JOINER, KA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (05) :1863-1867
[4]   CLONING OF A NOVEL BACTERIA-BINDING RECEPTOR STRUCTURALLY RELATED TO SCAVENGER RECEPTORS AND EXPRESSED IN A SUBSET OF MACROPHAGES [J].
ELOMAA, O ;
KANGAS, M ;
SAHLBERG, C ;
TUUKKANEN, J ;
SORMUNEN, R ;
LIAKKA, A ;
THESLEFF, I ;
KRAAL, G ;
TRYGGVASON, K .
CELL, 1995, 80 (04) :603-609
[5]   Quantitative aspiration during sleep in normal subjects [J].
Gleeson, K ;
Eggli, DF ;
Maxwell, SL .
CHEST, 1997, 111 (05) :1266-1272
[6]   Macrophage defences against respiratory tract infections [J].
Gordon, SB ;
Read, RC .
BRITISH MEDICAL BULLETIN, 2002, 61 :45-61
[7]   The scavenger receptor MARCO mediates cytoskeleton rearrangements in dendritic cells and microglia [J].
Granucci, F ;
Petralia, F ;
Urbano, M ;
Citterio, S ;
Di Tota, F ;
Santambrogio, L ;
Ricciardi-Castagnoli, P .
BLOOD, 2003, 102 (08) :2940-2947
[8]   RECOGNITION AND PLASMA-CLEARANCE OF ENDOTOXIN BY SCAVENGER RECEPTORS [J].
HAMPTON, RY ;
GOLENBOCK, DT ;
PENMAN, M ;
KRIEGER, M ;
RAETZ, CRH .
NATURE, 1991, 352 (6333) :342-344
[9]   The macrophage scavenger receptor type A is expressed by activated macrophages and protects the host against lethal endotoxic shock [J].
Haworth, R ;
Platt, N ;
Keshav, S ;
Hughes, D ;
Darley, E ;
Suzuki, H ;
Kurihara, Y ;
Kodama, T ;
Gordon, S .
JOURNAL OF EXPERIMENTAL MEDICINE, 1997, 186 (09) :1431-1439
[10]   Roles of a macrophage receptor with collagenous structure (MARCO) in host defense and heterogeneity of splenic marginal zone macrophages [J].
Ito, S ;
Naito, M ;
Kobayashi, Y ;
Takatsuka, H ;
Jiang, S ;
Usuda, H ;
Umezu, H ;
Hasegawa, G ;
Arakawa, M ;
Shultz, LD ;
Elomaa, O ;
Tryggvason, K .
ARCHIVES OF HISTOLOGY AND CYTOLOGY, 1999, 62 (01) :83-95