共 29 条
The scavenger receptor MARCO is required for lung defense against pneumococcal pneumonia and inhaled particles
被引:264
作者:

Arredouani, M
论文数: 0 引用数: 0
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机构: Harvard Univ, Sch Publ Hlth, Physiol Program, Boston, MA 02115 USA

Yang, ZP
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h-index: 0
机构: Harvard Univ, Sch Publ Hlth, Physiol Program, Boston, MA 02115 USA

Ning, YY
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h-index: 0
机构: Harvard Univ, Sch Publ Hlth, Physiol Program, Boston, MA 02115 USA

Qin, GZ
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h-index: 0
机构: Harvard Univ, Sch Publ Hlth, Physiol Program, Boston, MA 02115 USA

Soininen, R
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h-index: 0
机构: Harvard Univ, Sch Publ Hlth, Physiol Program, Boston, MA 02115 USA

Tryggvason, K
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h-index: 0
机构: Harvard Univ, Sch Publ Hlth, Physiol Program, Boston, MA 02115 USA

Kobzik, L
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h-index: 0
机构: Harvard Univ, Sch Publ Hlth, Physiol Program, Boston, MA 02115 USA
机构:
[1] Harvard Univ, Sch Publ Hlth, Physiol Program, Boston, MA 02115 USA
[2] Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA
[3] Univ Oulu, Bioctr, Dept Med Biochem & Mol Biol, Oulu 90014, Finland
[4] Karolinska Inst, Dept Med Biochem & Biophys, S-17177 Stockholm, Sweden
关键词:
macrophage;
phagocytosis;
environment;
innate immunity;
D O I:
10.1084/jem.20040731
中图分类号:
R392 [医学免疫学];
Q939.91 [免疫学];
学科分类号:
100102 ;
摘要:
Alveolar macrophages (AMs) express the class A scavenger receptor macrophage receptor with collagenous structure (MARCO), but its role in vivo in lung defense against bacteria and environmental particles has not been studied. We used MARCO-deficient mice to directly test the in vivo role of AM MARCO in innate defense against pneumococcal infection and environmental particles. In a murine model of pneumococcal pneumonia, MARCO(-/-) mice displayed an impaired ability to clear bacteria from the lungs, increased pulmonary inflammation and cytokine release, and diminished survival. In vitro binding of Streptococcus pneumoniae and in vivo uptake of unopsonized particles by MARCO(-/-) AMs were dramatically impaired. MARCO(-/-) mice treated with the "inert" environmental particle TiO2 showed enhanced inflammation and chemokine expression, indicating that MARCO-mediated clearance of inert particles by AMs prevents inflammatory responses otherwise initiated by other lung cells. Our findings point to an important role of MARCO in mounting an efficient and appropriately regulated innate immune response against inhaled particles and airborne pathogens.
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页码:267 / 272
页数:6
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