A Systematic Review of the Effectiveness of Intravenous Tranexamic Acid Administration in Managing Perioperative Blood Loss in Patients Undergoing Spine Surgery

被引：24
作者：
Badeaux, Jennifer [1 ]
Hawley, Diane [2 ]
机构：
[1] Louisiana State Univ, Hlth Sci Ctr, Nurse Anesthesia Program, New Orleans, LA 70112 USA
[2] Texas Christian Univ, Harris Coll Nursing & Hlth Sci, Ft Worth, TX 76129 USA
来源：
JOURNAL OF PERIANESTHESIA NURSING | 2014年 / 29卷 / 06期
关键词：
tranexamic acid or tranexamic; spine surgery or diskectomy or laminectomy or spinal fusion; blood loss; perioperative blood loss; intraoperative blood loss; postoperative blood loss; surgical blood loss; DOUBLE-BLIND; TRANSFUSION; EFFICACY; ANTIFIBRINOLYTICS; APROTININ; SCOLIOSIS; FUSION;
D O I：
10.1016/j.jopan.2014.06.003
中图分类号：
R47 [护理学];
学科分类号：
1011 ;
摘要：
This systematic review aimed to identify the effectiveness of intravenous tranexamic acid (TXA) administration in managing perioperative blood loss in patients undergoing spine surgery. The study design was a systematic review and meta-analysis. Quantitative articles were pooled in a statistical meta-analysis using the Joanna Briggs Institute Meta-Analysis of Statistical Assessment and Review Instrument. Twelve studies totaling 934 participants carried out between 1960 and 2013 were included in the review. Intraoperative blood loss showed statistically significant (P < .0001) blood loss in the control group compared with that in the treatment group. Perioperative blood loss was approaching significance for blood loss in the control group with an overall P = .067. TXA helps reduce perioperative blood loss for patients undergoing spine surgery. TXA should be administered to patients undergoing spine surgery when significant blood loss is anticipated.
引用
收藏
页码：459 / 465
页数：7
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