Visible light-induced hydroxyalkylation of 2H-benzothiazoles with alcohols via selectfluor oxidation

被引：22
作者：
Kong, Yaolei [1 ]
Xu, Wenxiu [1 ]
Liu, Xinghai [1 ]
Weng, Jianquan [1 ]
机构：
[1] Zhejiang Univ Technol, Coll Chem Engn, Hangzhou 310014, Peoples R China
来源：
CHINESE CHEMICAL LETTERS | 2020年 / 31卷 / 12期
基金：
中国国家自然科学基金;
关键词：
Visible light-induced; Hydroxyalkylation; 2H-Benzothiazole; Alcohol; Selectfluor; C-H BONDS; ALKYLATION REACTIONS; COUPLING REACTION; METAL; FLUORINATION; ACIDS; BENZOTHIAZOLES; DERIVATIVES; ETHERS;
D O I：
10.1016/j.cclet.2020.05.022
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A visible-light induced metal-free approach was described for the hydroxyalkylation of 2H-benzothiazoles with alcohols by using selectfluor as the oxidant. A variety of 2H-benzothiazoles and alcohols could be tolerated, providing a mild and simple method for the synthesis of C2-hydroxyalkylated 2H-benzothiazoles in moderate to good yields. Besides, ethers were also compatible in this reaction, leading to corresponding C2 ether-substituted 2H-benzothiazoles with high regioselectivity. (C) 2020 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：3245 / 3249
页数：5
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