Visible light-induced hydroxyalkylation of 2H-benzothiazoles with alcohols via selectfluor oxidation

被引：23

作者：

Kong, Yaolei ^{[1
]}

Xu, Wenxiu ^{[1
]}

Liu, Xinghai ^{[1
]}

Weng, Jianquan ^{[1
]}

机构：

[1] Zhejiang Univ Technol, Coll Chem Engn, Hangzhou 310014, Peoples R China

来源：

CHINESE CHEMICAL LETTERS | 2020年 / 31卷 / 12期

基金：

中国国家自然科学基金;

关键词：

Visible light-induced; Hydroxyalkylation; 2H-Benzothiazole; Alcohol; Selectfluor; C-H BONDS; ALKYLATION REACTIONS; COUPLING REACTION; METAL; FLUORINATION; ACIDS; BENZOTHIAZOLES; DERIVATIVES; ETHERS;

D O I：

10.1016/j.cclet.2020.05.022

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A visible-light induced metal-free approach was described for the hydroxyalkylation of 2H-benzothiazoles with alcohols by using selectfluor as the oxidant. A variety of 2H-benzothiazoles and alcohols could be tolerated, providing a mild and simple method for the synthesis of C2-hydroxyalkylated 2H-benzothiazoles in moderate to good yields. Besides, ethers were also compatible in this reaction, leading to corresponding C2 ether-substituted 2H-benzothiazoles with high regioselectivity. (C) 2020 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

引用

页码：3245 / 3249

页数：5

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