The function of the microtubule-associated protein tau is variably modulated by graded changes in glycogen synthase kinase-3β activity

被引：28
作者：
Leroy, K
Menu, R
Conreur, JL
Dayanandan, R
Lovestone, S
Anderton, BH
Brion, JP
机构：
[1] Free Univ Brussels, Sch Med, Lab Pathol & Electron Microscopy, B-1070 Brussels, Belgium
[2] Inst Psychiat, Dept Neurosci, London SE5 8AF, England
来源：
FEBS LETTERS | 2000年 / 465卷 / 01期
基金：
英国惠康基金;
关键词：
tau; glycogen synthase kinase-3 beta; microtubule; cell process; phosphorylation; lithium;
D O I：
10.1016/S0014-5793(99)01720-2
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The microtubule-associated protein tau favors microtubule nucleation and stabilization and plays a role in the elongation of axons. We have investigated the ability of glycogen synthase kinase-3 beta (GSK-3 beta) to control tau-induced processes outgrowth. Tau-transfected Chinese hamster ovary (CHO) cells developed processes containing microtubule bundles after cytochalasin treatment, but a significant reduction in the number of cells harboring processes was observed in tau/GSK-3 beta-cotransfected cells. Lithium, an inhibitor of GSK-3 beta, counteracted in a dose-dependent manner this inhibitory effect of GSK-3 beta. These findings suggest that GSK-3 beta modulates in a graded manner the ability of tau to control. the microtubule-dependent induction of cell processes. (C) 2000 Federation of European Biochemical Societies.
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收藏
页码：34 / 38
页数：5
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