Double JMY: making actin fast

被引：9

作者：

Roadcap, David W. ^{[1
]}

Bear, James E.

机构：

[1] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA

来源：

NATURE CELL BIOLOGY | 2009年 / 11卷 / 04期

关键词：

NUCLEATION; COFACTOR;

D O I：

10.1038/ncb0409-375

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The assembly of actin networks is dependent on nucleation-promoting factors. a new study identifies JMY as a protein containing two separate nucleation-promoting activities that shuttles between the nucleus and the cytoplasm and promotes cell migration. These observations indicate that JMY is an important factor controlling actin dynamics in motile cells.

引用

页码：375 / 376

页数：2

共 9 条

[1] WHAMM is an Arp2/3 complex activator that binds microtubules and functions in ER to Golgi transport [J].

Campellone, Kenneth G. ;

Webb, Neil J. ;

Znameroski, Elizabeth A. ;

Welch, Matthew D. .

CELL, 2008, 134 (01) :148-161

[2] Actin nucleation and elongation factors: mechanisms and interplay [J].

Chesarone, Melissa A. ;

Goode, Bruce L. .

CURRENT OPINION IN CELL BIOLOGY, 2009, 21 (01) :28-37

[3] Mdm2 targets the p53 transcription cofactor JMY for degradation [J].

Coutts, Amanda S. ;

Boulahbel, Houda ;

Graham, Anne ;

La Thangue, Nicholas B. .

EMBO REPORTS, 2007, 8 (01) :84-90

[4] Human subtelomeric WASH genes encode a new subclass of the WASP family [J].

Linardopoulou, Elena V. ;

Parghi, Sean S. ;

Friedman, Cynthia ;

Osborn, Gregory E. ;

Parkhurst, Susan M. ;

Trask, Barbara J. .

PLOS GENETICS, 2007, 3 (12) :2477-2485

[5] Catenins: Keeping cells from getting their signals crossed [J].

Perez-Moreno, Mirna ;

Fuchs, Elaine .

DEVELOPMENTAL CELL, 2006, 11 (05) :601-612

[6] Drosophila Spire is an actin nucleation factor [J].

Quinlan, ME ;

Heuser, JE ;

Kerkhoff, E ;

Mullins, RD .

NATURE, 2005, 433 (7024) :382-388

[7] A novel cofactor for p300 that regulates the p53 response [J].

Shikama, N ;

Lee, CW ;

France, S ;

Delavaine, L ;

Lyon, J ;

Krstic-Demonacos, M ;

La Thangue, NB .

MOLECULAR CELL, 1999, 4 (03) :365-376

[8] Nuclear actin dynamics - From form to function [J].

Vartiainen, Maria K. .

FEBS LETTERS, 2008, 582 (14) :2033-2040

[9] p53-cofactor JMY is a multifunctional actin nucleation factor [J].

Zuchero, J. Bradley ;

Coutts, Amanda S. ;

Quinlan, Margot E. ;

La Thangue, Nicholas B. ;

Mullins, R. Dyche .

NATURE CELL BIOLOGY, 2009, 11 (04) :451-U198

← 1 →