Cohort profile: Stop the Spread Ottawa (SSO)-a community-based prospective cohort study on antibody responses, antibody neutralisation efficiency and cellular immunity to SARS-CoV-2 infection and vaccination

被引：14

作者：

Collins, Erin ^{[1
,2
]}

Galipeau, Yannick ^{[3
]}

Arnold, Corey ^{[3
]}

Bosveld, Cameron ^{[4
]}

Heiskanen, Aliisa ^{[1
,2
]}

Keeshan, Alexa ^{[1
,2
]}

Nakka, Kiran ^{[3
,5
]}

Shir-Mohammadi, Khatereh ^{[3
]}

St-Denis-Bissonnette, Frederic ^{[4
]}

Tamblyn, Laura ^{[4
]}

Vranjkovic, Agatha ^{[4
]}

Wood, Leah C. ^{[4
]}

Booth, Ronald ^{[6
,7
]}

Buchan, C. Arianne ^{[8
,9
]}

Crawley, Angela M. ^{[3
,4
,10
,11
]}

Little, Julian ^{[1
,2
,10
,12
]}

McGuinty, Michaeline ^{[8
,9
]}

Saginur, Raphael ^{[8
,9
,13
]}

Langlois, Marc-Andre ^{[3
,10
,11
]}

Cooper, Curtis L. ^{[2
,8
,9
,10
,11
]}

机构：

[1] Univ Ottawa, Fac Med, Sch Epidemiol & Publ Hlth, Ottawa, ON, Canada

[2] Ottawa Hosp Res Inst, Clin Epidemiol, Ottawa, ON, Canada

[3] Univ Ottawa, Dept Biochem Microbiol & Immunol, Ottawa, ON, Canada

[4] Ottawa Hosp Res Inst, Chron Dis Program, Ottawa, ON, Canada

[5] Ottawa Hosp Res Inst, Sprott Ctr Stem Cell Res, Regenerat Med Program, Ottawa, ON, Canada

[6] Univ Ottawa, Dept Pathol & Lab Med, Ottawa, ON, Canada

[7] Eastern Ontario Reg Lab Assoc EORLA, Immunol Sect, Ottawa, ON, Canada

[8] Ottawa Hosp Res Inst, Dept Med, Div Infect Dis, Ottawa, ON, Canada

[9] Univ Ottawa, Fac Med, Ottawa, ON, Canada

[10] Univ Ottawa, Fac Med, Coronavirus Variants Rapid Response Network CoVaRR, Ottawa, ON, Canada

[11] Univ Ottawa, Ctr Infect Immun & Inflammat CI3, Ottawa, ON, Canada

[12] Univ Ottawa, Knowledge Synth & Applicat Unit KSAU, Ottawa, ON, Canada

[13] Ottawa Hosp Res Inst, Ottawa Hlth Sci Network Res Eth Board OHSN REB, Ottawa, ON, Canada

来源：

BMJ OPEN | 2022年 / 12卷 / 09期

基金：

加拿大健康研究院;

关键词：

COVID-19; virology; infectious diseases; epidemiology; public health; immunology; COVID-19; VACCINES;

D O I：

10.1136/bmjopen-2022-062187

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

PurposeTo investigate the robustness and longevity of SARS-CoV-2 immune responses conferred by natural infection and vaccination among priority populations such as immunocompromised individuals and people with post-acute sequelae of COVID-19 in a prospective cohort study (Stop the Spread Ottawa-SSO) in adults living in the Ottawa region. In this paper, we describe the study design, ongoing data collection and baseline characteristics of participants.ParticipantsSince October 2020, participants who tested positive for COVID-19 (convalescents) or at high risk of exposure to the virus (under surveillance) have provided monthly blood and saliva samples over a 10-month period. As of 2 November 2021, 1026 adults had completed the baseline survey and 976 had attended baseline bloodwork. 300 participants will continue to provide bimonthly blood samples for 24 additional months (ie, total follow-up of 34 months).Findings to dateThe median age of the baseline sample was 44 (IQR 23, range: 18-79) and just over two-thirds (n=688; 67.1%) were female. 255 participants (24.9%) had a history of COVID-19 infection confirmed by PCR and/or serology. Over 600 participants (60.0%) work in high-risk occupations (eg, healthcare, teaching and transportation). 108 participants (10.5%) reported immunocompromising conditions or treatments at baseline (eg, cancer, HIV, other immune deficiency, and/or use of immunosuppressants).Future plansSSO continues to yield rich research potential, given the collection of pre-vaccine baseline data and samples from the majority of participants, recruitment of diverse subgroups of interest, and a high level of participant retention and compliance with monthly sampling. The 24-month study extension will maximise opportunities to track SARS-CoV-2 immunity and vaccine efficacy, detect and characterise emerging variants, and compare subgroup humoral and cellular response robustness and persistence.

引用

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