Electrospinning of polymeric nanofibers for drug delivery applications

被引：912
作者：
Hu, Xiuli [1 ]
Liu, Shi [1 ,3 ]
Zhou, Guangyuan [2 ]
Huang, Yubin [1 ]
Xie, Zhigang [1 ]
Jing, Xiabin [1 ]
机构：
[1] Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China
[2] Chinese Acad Sci, Changchun Inst Appl Chem, Key Lab Polymer Ecomat, Changchun 130022, Peoples R China
[3] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
来源：
JOURNAL OF CONTROLLED RELEASE | 2014年 / 185卷
基金：
中国国家自然科学基金;
关键词：
Electrospinning; Drug delivery; Wound dressing; Local chemotherapy; CONTROLLED ANTIBIOTIC RELEASE; PROTECTIVE TEXTILE MATERIALS; GLIOMA IN-VITRO; CORE-SHEATH; TETRACYCLINE HYDROCHLORIDE; BIODEGRADABLE FIBERS; SURFACE-MORPHOLOGY; SUSTAINED DELIVERY; POLYSTYRENE FIBERS; MOLECULAR-WEIGHT;
D O I：
10.1016/j.jconrel.2014.04.018
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Electrospinning has been recognized as a simple and versatile method for fabrication of polymer nanofibers. Various polymers that include synthetic, natural, and hybrid materials have been successfully electrospun into ultrafine fibers. The inherently high surface to volume ratio of electrospun fibers can enhance cell attachment, drug loading, and mass transfer properties. Drugs ranging from antibiotics and anticancer agents to proteins, DNA, RNA, living cells, and various growth factors have been incorporated into electrospun fibers. This article presents an overview of electrospinning techniques and their application in drug delivery. (C) 2014 Elsevier B.V. All rights reserved.
引用
收藏
页码：12 / 21
页数：10
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