Electrospinning of polymeric nanofibers for drug delivery applications

被引：912

作者：

Hu, Xiuli ^{[1
]}

Liu, Shi ^{[1
,3
]}

Zhou, Guangyuan ^{[2
]}

Huang, Yubin ^{[1
]}

Xie, Zhigang ^{[1
]}

Jing, Xiabin ^{[1
]}

机构：

[1] Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China

[2] Chinese Acad Sci, Changchun Inst Appl Chem, Key Lab Polymer Ecomat, Changchun 130022, Peoples R China

[3] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

来源：

JOURNAL OF CONTROLLED RELEASE | 2014年 / 185卷

基金：

中国国家自然科学基金;

关键词：

Electrospinning; Drug delivery; Wound dressing; Local chemotherapy; CONTROLLED ANTIBIOTIC RELEASE; PROTECTIVE TEXTILE MATERIALS; GLIOMA IN-VITRO; CORE-SHEATH; TETRACYCLINE HYDROCHLORIDE; BIODEGRADABLE FIBERS; SURFACE-MORPHOLOGY; SUSTAINED DELIVERY; POLYSTYRENE FIBERS; MOLECULAR-WEIGHT;

D O I：

10.1016/j.jconrel.2014.04.018

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Electrospinning has been recognized as a simple and versatile method for fabrication of polymer nanofibers. Various polymers that include synthetic, natural, and hybrid materials have been successfully electrospun into ultrafine fibers. The inherently high surface to volume ratio of electrospun fibers can enhance cell attachment, drug loading, and mass transfer properties. Drugs ranging from antibiotics and anticancer agents to proteins, DNA, RNA, living cells, and various growth factors have been incorporated into electrospun fibers. This article presents an overview of electrospinning techniques and their application in drug delivery. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：12 / 21

页数：10

共 112 条

[1]

Anton F., 1934, US patent, Patent No. [US1975504A, 1975504, 1975504A]

[2] Separation of micron to sub-micron particles from water: Electrospun nylon-6 nanofibrous membranes as pre-filters [J].

Aussawasathien, D. ;

Teerawattananon, C. ;

Vongachariya, A. .

JOURNAL OF MEMBRANE SCIENCE, 2008, 315 (1-2) :11-19

[3] Co-electrospinning of core-shell fibers using a single-nozzle technique [J].

Bazilevsky, Alexander V. ;

Yarin, Alexander L. ;

Megaridis, Constantine M. .

LANGMUIR, 2007, 23 (05) :2311-2314

[4] Electrospinning: A fascinating fiber fabrication technique [J].

Bhardwaj, Nandana ;

Kundu, Subhas C. .

BIOTECHNOLOGY ADVANCES, 2010, 28 (03) :325-347

[5] RNA interference by nanofiber-based siRNA delivery system [J].

Cao, Haoqing ;

Jiang, Xu ;

Chai, Chou ;

Chew, Sing Yian .

JOURNAL OF CONTROLLED RELEASE, 2010, 144 (02) :203-212

[6] Controlling surface morphology of electrospun polystyrene fibers: Effect of humidity and molecular weight in the electrospinning process [J].

Casper, CL ;

Stephens, JS ;

Tassi, NG ;

Chase, DB ;

Rabolt, JF .

MACROMOLECULES, 2004, 37 (02) :573-578

[7] Electrohydrodynamics: A facile technique to fabricate drug delivery systems [J].

Chakraborty, Syandan ;

Liao, I-Chien ;

Adler, Andrew ;

Leong, Kam W. .

ADVANCED DRUG DELIVERY REVIEWS, 2009, 61 (12) :1043-1054

[8] Electrospinning of type I collagen and PCL nanofibers using acetic acid [J].

Chakrapani, V. Yogeshwar ;

Gnanamani, A. ;

Giridev, V. R. ;

Madhusoothanan, M. ;

Sekaran, G. .

JOURNAL OF APPLIED POLYMER SCIENCE, 2012, 125 (04) :3221-3227

[9] Aligned protein-polymer composite fibers enhance nerve regeneration: A potential tissue-engineering platform [J].

Chew, Sing Yian ;

Mi, Ruifa ;

Hoke, Ahmet ;

Leong, Kam W. .

ADVANCED FUNCTIONAL MATERIALS, 2007, 17 (08) :1288-1296

[10] Sustained release of proteins from electrospun biodegradable fibers [J].

Chew, SY ;

Wen, J ;

Yim, EKF ;

Leong, KW .

BIOMACROMOLECULES, 2005, 6 (04) :2017-2024

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