Tyrosine conjugated zinc(II) phthalocyanine for photodynamic therapy: Synthesis and photophysicochemical properties

被引：12
|
作者：
Aliosman, Meliha [1 ,2 ]
Goksel, Meltem [1 ,3 ]
Mantareva, Vanya [2 ]
Stoineva, Ivanka [2 ]
Durmus, Mahmut [1 ]
机构：
[1] Gebze Tech Univ, Dept Chem, TR-41400 Gebze, Kocaeli, Turkey
[2] Bulgarian Acad Sci, Inst Organ Chem, Ctr Phytochem, Acad G Bonchev,Bld 9, BU-1113 Sofia, Bulgaria
[3] Kocaeli Univ, Kosekoy Vocat Sch, TR-41135 Kartepe, Kocaeli, Turkey
来源：
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY | 2017年 / 334卷
关键词：
Photodynamic therapy; Tyrosine; Zn(II) phthalocyanine; Fluorescence; Singlet oxygen; Photostability; PORPHYRIN; PHOTOSENSITIZERS; FLUORESCENCE; GALLIUM(III);
D O I：
10.1016/j.jphotochem.2016.10.037
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Biologically active photosensitizers with long absorption wavelength are among the new generation drugs for potential application in photodynamic therapy (PDT). This study presents a new phthalocyanine photosensitizer functionalized with amino acid for application in PDT. This photosensitizer, tetra-(4-tyrosylamido) phenoxy substituted zinc(II) phthalocyanine (ZnPcTyr), was synthesized and chemically characterized. The properties of electronic absorption, fluorescence, photostability, and singlet oxygen generation were studied. The obtained photophysicochemical characteristics suggested that this newly synthesized tyrosine conjugated zinc(II) phthalocyanine has promising potential as photosensitizer for photodynamic therapy. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码：101 / 106
页数：6
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