Inhibition and Induction of Quorum Sensing Using Complexes between N-Acylhomoserine Lactone and Self-assembled Polymer Micelles

被引：3

作者：

Okano, Chigusa ^{[1
]}

Kato, Norihiro ^{[2
,3
]}

机构：

[1] Utsunomiya Univ, Grad Sch Engn, Dept Innovat Syst Engn, Utsunomiya, Tochigi 3218585, Japan

[2] Japan Sci & Technol Agcy, CREST, Utsunomiya, Tochigi 3218585, Japan

[3] Utsunomiya Univ, Grad Sch Engn, Dept Mat & Environm Chem, Utsunomiya, Tochigi 3218585, Japan

来源：

CHEMISTRY LETTERS | 2015年 / 44卷 / 11期

基金：

日本科学技术振兴机构;

关键词：

GRAM-NEGATIVE BACTERIA; VIBRIO-FISCHERI; COPOLYMERS; VIRULENCE; SERRATIA; DNA;

D O I：

10.1246/cl.150729

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A self-assembled micelle of a triblock copolymer, poloxamer 407, effectively forms a complex with N-acylhomoserine lactone (AHL) as a quorum-sensing (QS) signal in Gram-negative bacteria. The inhibitory effect of the poloxamer on QS in Serratia marcescens AS-1 enhanced at a concentration above a critical micelle concentration (CMC). The poloxamer micelle constitutes a novel class of QS regulator, which can activate the QS in AHLnegative strain S. marcescens AS-1S by the released AM, from AHL-loaded micelles added from outside.

引用

页码：1544 / 1546

页数：3