One-pot efficient green synthesis of 1,4-dihydro-quinoxaline-2,3-dione derivatives

被引：37

作者：

Thakuria, Harjyotl ^{[1
]}

Das, Gopal ^{[1
]}

机构：

[1] Indian Inst Technol Guwahati, Dept Chem, Gauhati 781039, India

来源：

JOURNAL OF CHEMICAL SCIENCES | 2006年 / 118卷 / 05期

关键词：

Green chemistry; quinoxaline; o-phenylene diamine; oxalic acid; grinding; atom economy;

D O I：

10.1007/BF02711453

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient synthesis of the potential pharmacophore 1,4-dihydro-quinoxaline-2,3-dione (1) has been achieved in a one-pot reaction at room temperature from substituted o-phenylene diamine and oxalic acid under solvent-free conditions by a simple grinding method with unsurpassed atom economy. Thermal and powder X-ray diffraction analysis was carried out for some hydrated crystals.

引用

页码：425 / 428

页数：4

共 10 条

[1] Lead discovery of quinoxalinediones as an inhibitor of dipeptidyl peptidase-IV (DPP-IV) by high-throughput screening [J].

Cheon, HG ;

Lee, CM ;

Kim, BT ;

Hwang, KJ .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2004, 14 (10) :2661-2664

[2] Structures and solid-state dynamics of one-dimensional water chains stabilized by imidazole channels [J].

Cheruzel, LE ;

Pometun, MS ;

Cecil, MR ;

Mashuta, MS ;

Wittebort, RJ ;

Buchanan, RM .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2003, 42 (44) :5452-5455

[3] Experimental and ab initio calculational studies on 2,3-diketo-benzopiperazine [J].

Jian, FF ;

Zhao, PS .

JOURNAL OF MOLECULAR STRUCTURE, 2004, 705 (1-3) :133-139

[4]

Kaupp G, 2002, EUR J ORG CHEM, V2002, P1368

[5] Excitatory amino acids [J].

Moloney, MG .

NATURAL PRODUCT REPORTS, 2002, 19 (05) :597-616

[6] Water superstructures within organic arrays; Hydrogen-bonded water sheets, chains and clusters [J].

Oxtoby, NS ;

Blake, AJ ;

Champness, NR ;

Wilson, C .

CHEMISTRY-A EUROPEAN JOURNAL, 2005, 11 (16) :4643-4654

[7]

SCHNEIDER S, 1991, REV COMPUTATIONAL CH, V2

[8] Synthesis and characterization of a tetrazolate-bridged coordination framework encapsulating D2h-symmetric cyclic (H2O)4 cluster arrays [J].

Tao, J ;

Ma, ZJ ;

Huang, RB ;

Zheng, LS .

INORGANIC CHEMISTRY, 2004, 43 (20) :6133-6135

[9] A one-pot synthesis and self-assembled superstructure of organic salts of a 1,5-benzodiazepine derivative [J].

Thakuria, H ;

Pramanik, A ;

Borah, BM ;

Das, G .

TETRAHEDRON LETTERS, 2006, 47 (18) :3135-3138

[10] Ytterbium triflate catalyzed heterocyclization of 1,2-phenylenediamines and alkyl oxalates under solvent-free conditions via Phillips reaction: A facile synthesis of quinoxaline-2,3-diones derivatives [J].

Wang, LM ;

Liu, JJ ;

Tian, H ;

Qian, CT .

SYNTHETIC COMMUNICATIONS, 2004, 34 (08) :1349-1357

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