Ultrasound-mediated oxygen delivery from chitosan nanobubbles

被引：73
|
作者：
Cavalli, Roberta [1 ]
Bisazza, Agnese [1 ]
Rolfo, Alessandro [2 ]
Balbis, Sonia [3 ]
Madonnaripa, Daniele [4 ]
Caniggia, Isabella [2 ]
Guiot, Caterina [3 ]
机构：
[1] Univ Turin, Dipartimento Sci & Tecnol Farmaco, I-10125 Turin, Italy
[2] Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Dept Obstet & Gynecol, Toronto, ON M5G 1X5, Canada
[3] Univ Turin, Dipartimento Neurosci, I-10125 Turin, Italy
[4] Ist Elettrotecn Nazl Galileo Ferraris Torino, Dipartimento Acust, I-10126 Turin, Italy
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2009年 / 378卷 / 1-2期
关键词：
Microbubbles; Oxygen; Ultrasound; Chitosan; Hypoxia; TUMOR HYPOXIA; MICROBUBBLES; BUBBLES;
D O I：
10.1016/j.ijpharm.2009.05.058
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Ultrasound (US) energy combined with gas-filled microbubbles has been used for several years in medical imaging. This study investigated the ability of oxygen-loaded chitosan bubbles to exchange oxygen in the presence or in the absence of US. Oxygen delivery is enhanced by sonication and both frequency and time duration of US affected the exchange kinetics. (C) 2009 Elsevier B.V. All rights reserved.
引用
收藏
页码：215 / 217
页数：3
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