Targeting BRD9 for Cancer Treatment: A New Strategy

被引：30

作者：

Zhu, Xiuzuo ^{[1
]}

Liao, Yi ^{[2
]}

Tang, Liling ^{[1
]}

机构：

[1] Chongqing Univ, Coll Bioengn, Key Lab Biorheol Sci & Technol, Minist Educ, Chongqing, Peoples R China

[2] Third Mil Med Univ, Southwest Hosp, Dept Thorac Surg, Army Med Univ, Chongqing, Peoples R China

来源：

ONCOTARGETS AND THERAPY | 2020年 / 13卷

关键词：

BRD9; ncBAF; bromodomain; cancer; inhibitor; MUTATIONAL LANDSCAPE; CELL-PROLIFERATION; HUMAN BROMODOMAINS; SOMATIC MUTATIONS; GENETIC LANDSCAPE; SWI/SNF COMPLEXES; GENOMIC LANDSCAPE; HISTONE PEPTIDE; WHOLE-GENOME; BETA-CELL;

D O I：

10.2147/OTT.S286867

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Bromodomain-containing protein 9 (BRD9) is a newly identified subunit of the non-canonical barrier-to-autointegration factor (ncBAF) complex and a member of the bromodomain family IV. Studies have confirmed that BRD9 plays an oncogenic role in multiple cancer types, by regulating tumor cell growth. The tumor biological functions of BRD9 are mainly due to epigenetic modification mediated by its bromodomain. The bromodomain recruits the ncBAF complex to the promoter to regulate gene transcription. This review summarizes the potential mechanisms of action of BRD9 in carcinogenesis and the emerging strategies for targeting BRD9 for cancer therapeutics. Although the therapeutic potential of BRD9 has been exploited to some extent, research on the detailed biological mechanisms of BRD9 is still in its infancy. Therefore, targeting BRD9 to study its biological roles will be an attractive tool for cancer diagnosis and treatment, but it remains a great challenge.

引用

页码：13191 / 13200

页数：10

共 123 条

[1] Jmjd2/Kdm4 demethylases are required for expression of Il3ra and survival of acute myeloid leukemia cells [J].

Agger, Karl ;

Miyagi, Satoru ;

Pedersen, Marianne Terndrup ;

Kooistra, Susanne M. ;

Johansen, Jens Vilstrup ;

Helin, Kristian .

GENES & DEVELOPMENT, 2016, 30 (11) :1278-1288

[2] Glioma tumor suppressor candidate region gene 1 (GLTSCR1) and its paralog GLTSCR1-like form SWI/SNF chromatin remodeling subcomplexes [J].

Alpsoy, Aktan ;

Dykhuizen, Emily C. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2018, 293 (11) :3892-3903

[3] Long-term survival and transmission of INII-mutation via nonpenetrant males in a family with rhabdoid tumour predisposition syndrome [J].

Ammerlaan, A. C. J. ;

Ararou, A. ;

Houben, M. P. W. A. ;

Baas, F. ;

Tijssen, C. C. ;

Teepen, J. L. J. M. ;

Wesseling, P. ;

Hulsebos, T. J. M. .

BRITISH JOURNAL OF CANCER, 2008, 98 (02) :474-479

[4] Lung cancer: some progress, but still a lot more to do [J].

不详 .

LANCET, 2019, 394 (10212) :1880-1880

[5] Diabetes Mellitus and the β Cell: The Last Ten Years [J].

Ashcroft, Frances M. ;

Rorsman, Patrik .

CELL, 2012, 148 (06) :1160-1171

[6] DUSP6 regulates drug sensitivity by modulating DNA damage response [J].

Bagnyukova, T. V. ;

Restifo, D. ;

Beeharry, N. ;

Gabitova, L. ;

Li, T. ;

Serebriiskii, I. G. ;

Golemis, E. A. ;

Astsaturov, I. .

BRITISH JOURNAL OF CANCER, 2013, 109 (04) :1063-1071

[7] The SS18-SSX Oncoprotein Hijacks KDM2B-PRC1.1 to Drive Synovial Sarcoma [J].

Banito, Ana ;

Li, Xiang ;

Laporte, Aimee N. ;

Roe, Jae-Seok ;

Sanchez-Vega, Francisco ;

Huang, Chun-Hao ;

Dancsok, Amanda R. ;

Hatzi, Katerina ;

Chen, Chi-Chao ;

Tschaharganeh, Darjus F. ;

Chandwani, Rohit ;

Tasdemir, Nilgun ;

Jones, Kevin B. ;

Capecchi, Mario R. ;

Vakoc, Christopher R. ;

Schultz, Nikolaus ;

Ladanyi, Marc ;

Nielsen, Torsten O. ;

Lowe, Scott W. .

CANCER CELL, 2018, 33 (03) :527-+

[8] PIK3CA Cooperates with KRAS to Promote MYC Activity and Tumorigenesis via the Bromodomain Protein BRD9 [J].

Bell, Catherine M. ;

Raffeiner, Philipp ;

Hart, Jonathan R. ;

Vogt, Peter K. .

CANCERS, 2019, 11 (11)

[9] GSK2801, a BAZ2/BRD9 Bromodomain Inhibitor, Synergizes with BET Inhibitors to Induce Apoptosis in Triple-Negative Breast Cancer [J].

Bevill, Samantha M. ;

Olivares-Quintero, Jose F. ;

Sciaky, Noah ;

Golitz, Brian T. ;

Singh, Darshan ;

Beltran, Adriana S. ;

Rashid, Naim U. ;

Stuhlmiller, Timothy J. ;

Hale, Andrew ;

Moorman, Nathaniel J. ;

Santos, Charlene M. ;

Angus, Steven P. ;

Zawistowski, Jon S. ;

Johnson, Gary L. .

MOLECULAR CANCER RESEARCH, 2019, 17 (07) :1503-1518

[10] Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes [J].

Biankin, Andrew V. ;

Waddell, Nicola ;

Kassahn, Karin S. ;

Gingras, Marie-Claude ;

Muthuswamy, Lakshmi B. ;

Johns, Amber L. ;

Miller, David K. ;

Wilson, Peter J. ;

Patch, Ann-Marie ;

Wu, Jianmin ;

Chang, David K. ;

Cowley, Mark J. ;

Gardiner, Brooke B. ;

Song, Sarah ;

Harliwong, Ivon ;

Idrisoglu, Senel ;

Nourse, Craig ;

Nourbakhsh, Ehsan ;

Manning, Suzanne ;

Wani, Shivangi ;

Gongora, Milena ;

Pajic, Marina ;

Scarlett, Christopher J. ;

Gill, Anthony J. ;

Pinho, Andreia V. ;

Rooman, Ilse ;

Anderson, Matthew ;

Holmes, Oliver ;

Leonard, Conrad ;

Taylor, Darrin ;

Wood, Scott ;

Xu, Qinying ;

Nones, Katia ;

Fink, J. Lynn ;

Christ, Angelika ;

Bruxner, Tim ;

Cloonan, Nicole ;

Kolle, Gabriel ;

Newell, Felicity ;

Pinese, Mark ;

Mead, R. Scott ;

Humphris, Jeremy L. ;

Kaplan, Warren ;

Jones, Marc D. ;

Colvin, Emily K. ;

Nagrial, Adnan M. ;

Humphrey, Emily S. ;

Chou, Angela ;

Chin, Venessa T. ;

Chantrill, Lorraine A. .

NATURE, 2012, 491 (7424) :399-405

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