Associations of BMI, waist circumference, body fat, and skeletal muscle with type 2 diabetes in adults

被引:47
作者
Han, T. S. [1 ,2 ]
Al-Gindan, Y. Y. [3 ,4 ]
Govan, L. [5 ]
Hankey, C. R. [3 ]
Lean, M. E. J. [3 ]
机构
[1] Royal Holloway Univ London, Inst Cardiovasc Res, Egham, Surrey, England
[2] Ashford & St Peters NHS Fdn Trust, Dept Diabet & Endocrinol, Chertsey, England
[3] Univ Glasgow, Dept Nutr, Sch Med, Glasgow, Lanark, Scotland
[4] Imam Abdulrahman bin Faisal Univ, Dept Clin Nutr, Dammam, Saudi Arabia
[5] Univ Glasgow, Inst Hlth & Wellbeing, Hlth Econ & Hlth Technol Assessment, Glasgow, Lanark, Scotland
基金
中国国家自然科学基金;
关键词
Anthropometry; Obesity; Health surveys; Adiposity; MASS INDEX; INDEPENDENTLY CONTRIBUTE; INSULIN-RESISTANCE; HIP CIRCUMFERENCE; OBESITY; RISK; HEALTH; RATIO;
D O I
10.1007/s00592-019-01328-3
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
AimsType 2 diabetes (T2D) is known to be associated with high BMI and waist circumference (WC). These measures do not discriminate well between skeletal muscle (SM) and body fat (BF), which may have opposite influences.MethodsWe conducted a secondary analysis of population-based data from 58,128 aged 18-85 yrs from Scottish Health Surveys (2003, 2008-2011) and Health Surveys for England (2003-2006, 2008-2013), excluding pregnant women and insulin-treated diabetes. Logistic regression was used to assess associations of known T2D, and of screened HbA1c>48mmol/mol (>6.5%), with sex-specific quintiles of BMI, WC, and BF% and SM% estimated by validated anthropometric equations, adjusted for age, sex, smoking, ethnicity, country, and survey year.ResultsAs expected, ORs for having known T2D rose with quintiles of BMI (1, 1.5, 2.3, 3.1, and 6.5) and WC (1, 1.8, 2.5, 3.5, and 8.7). Compared to the lowest BF% quintile, OR for having T2D in highest BF% quintile was 11.1 (95% CI=8.4-14.6). Compared to the highest SM% quintile, OR for having T2D in lowest SM% quintile was 2.0 (1.7-2.4). Of 72 adults with T2D/HbA1c>6.5% in the lowest quintile of BF%, 27 (37.5%) were in quintile 1 of SM%. Similar patterns of OR were observed for having HbA1c>6.5% in those without known T2D.ConclusionsEstimated BF% associates strongly with T2D. Low SM% also has a significant association, suggesting a neglected aspect of aetiology within T2D. These two simple measures with biological relevance, available from data collected in most health surveys, may be more useful than the purely statistical terms BMI.
引用
收藏
页码:947 / 954
页数:8
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