Risk of psychiatric disorders in irritable bowel syndromeA nationwide, population-based, cohort study

被引：25
作者：
Yeh, Hui-Wen [1 ,2 ,3 ,4 ,5 ]
Chien, Wu-Chien [6 ,7 ,8 ]
Chung, Chi-Hsiang [6 ,7 ,9 ]
Hu, Je-Ming [10 ,11 ,12 ]
Tzeng, Nian-Sheng [3 ,13 ]
机构：
[1] Natl Chiao Tung Univ, Inst Bioinformat & Syst Biol, Hsinchu, Taiwan
[2] Kang Ning Univ, Dept Nursing, Taipei Campus, Taipei, Taiwan
[3] Triserv Gen Hosp, Natl Def Med Ctr, Sch Med, Dept Psychiat, Taipei, Taiwan
[4] Triserv Gen Hosp, Dept Nursing, Taipei, Taiwan
[5] Natl Def Med Ctr, Sch Nursing, Taipei, Taiwan
[6] Triserv Gen Hosp, Natl Def Med Ctr, Dept Med Res, Taipei, Taiwan
[7] Natl Def Med Ctr, Sch Publ Hlth, Taipei, Taiwan
[8] Natl Def Med Ctr, Grad Inst Life Sci, Taipei, Taiwan
[9] Taiwanese Injury Prevent & Safety Promot Assoc, Taipei, Taiwan
[10] Triserv Gen Hosp, Natl Def Med Ctr, Sch Med, Dept Surg,Div Colorectal Surg, Taipei, Taiwan
[11] Triserv Gen Hosp, Natl Def Med Ctr, Sch Med, Dept Emergency Med, Taipei, Taiwan
[12] Natl Def Med Ctr, Grad Inst Med Sci, Taipei, Taiwan
[13] Natl Def Med Ctr, Student Counseling Ctr, Taipei, Taiwan
来源：
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE | 2018年 / 72卷 / 07期
关键词：
ACUTE ISCHEMIC-STROKE; ANOREXIA-NERVOSA; CLAIMS DATABASE; GUT-MICROBIOTA; TAIWAN; PREVALENCE; VALIDATION; HEALTH; DEPRESSION; DIAGNOSIS;
D O I：
10.1111/ijcp.13212
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
AimsThis cohort study aimed to investigate the association between irritable bowel syndrome (IBS) and the risk of developing psychiatric disorders. MethodsUtilizing the National Health Insurance Research Database (NHIRD) of Taiwan, IBS patients were identified and compared with age, sex, and index year-matched controls (1:3). ResultsOf the IBS subjects, 3934 in 22356 (17.60%, or 1533.68 per 100000 person-years) developed psychiatric disorders when compared with 6127 in 67068 (9.14%, or 802 per 100000 person-years) in the non-IBS control group. Fine and Gray's survival analysis revealed that the study subjects were more likely to develop psychiatric disorders. The crude hazard ratio (HR) is 3.767 (95% CI: 3.614-3.925, P<.001), and the adjusted HR is 3.598 (95% CI: 3.452-3.752, P<.001) in the risk of developing psychiatric disorders after being adjusted for age, sex, comorbidities, geographical area of residence, urbanisation level of residence, and monthly insurance premiums. The cohort study revealed that IBS subjects were associated with an increased risk of anxiety, depression, bipolar, and sleep disorders. ConclusionsThis cohort study, using NHIRD, shows evidence support that patients with IBS have a 3.6-fold risk of developing psychiatric disorders. Other large or national datasets should be done to explore to underlying mechanisms.
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页数：8
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