Cortisol controlled release by mesoporous silica

被引：23

作者：

Lopez, Tessy ^{[1
,2
]}

Ortiz, Emma ^{[2
]}

Alexander-Katz, Roberto ^{[3
]}

Basaldella, Elena ^{[4
]}

Bokhimi, Xim ^{[5
]}

机构：

[1] Univ Autonoma Metropolitana Xochimilco, Dept Atenc Salud, Mexico City, DF, Mexico

[2] Inst Nacl Neurol & Neurocirugia MVS, Mexico City, DF, Mexico

[3] Univ Autonoma Metropolitana Iztapalapa, Dept Fis, Mexico City, DF, Mexico

[4] Univ Nacl La Plata, CIC, CINDECA, La Plata, Buenos Aires, Argentina

[5] Univ Nacl Autonoma Mexico, Inst Fis, Mexico City 01000, DF, Mexico

来源：

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE | 2009年 / 5卷 / 02期

关键词：

Hydrocortisone; Mesoporous; Ordered silicas; Drug release; Sol-gel; DRUG-DELIVERY; NEURODEGENERATIVE DISEASES; VALPROIC ACID; TEMPORAL-LOBE; TITANIA; SYSTEM; PHENYTOIN; SOLIDS; BRAIN; MICROPARTICLES;

D O I：

10.1016/j.nano.2008.08.002

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

In this study four types of SBAs were synthesized and then impregnated with hydrocortisone. One is a straight SBA-15, obtained using Pluronics P123 as structuring agent; two others were modified using 1,3,5-trimethylbenzene as additive, and the fourth one was prepared using sodium iodide as additive. Three of these have in common a p6mm symmetry with nanotubes packed hexagonally, yet they differ in their functional groups. The fourth sample is basically disordered. The drug release kinetics showed two stages: a fast-rate early stage dominated by the controlled release of the hydrocortisone adsorbed in the macropores of the reservoir, followed by a slow-rate delivery that we assume is controlled by the hydrocortisone diffusion through the nanopores. It is shown that the release kinetics can be strongly influenced by using different co-additives. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：170 / 177

页数：8

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