Phenotypic Spectrum of Heart Failure with Preserved Ejection Fraction

被引：144

作者：

Shah, Sanjiv J. ^{[1
]}

Katz, Daniel H. ^{[2
]}

Deo, Rahul C. ^{[3
]}

机构：

[1] Northwestern Univ, Feinberg Sch Med, Feinberg Cardiovasc Res Inst, Dept Med,Div Cardiol,Preserved Eject Fract Progra, Chicago, IL 60611 USA

[2] Northwestern Univ, Feinberg Sch Med, Feinberg Cardiovasc Res Inst, Dept Med,Div Cardiol, Chicago, IL USA

[3] Univ Calif San Francisco, Cardiovasc Res Inst, Dept Med, Div Cardiol, San Francisco, CA 94143 USA

来源：

HEART FAILURE CLINICS | 2014年 / 10卷 / 03期

基金：

美国国家卫生研究院;

关键词：

Heart failure with preserved ejection fraction; Phenotype; Phenomics; Etiology; Pathophysiology; Classification; Clinical trials; DIASTOLIC STRESS ECHOCARDIOGRAPHY; PULMONARY-HYPERTENSION; COMORBIDITIES; DYSFUNCTION; MANAGEMENT; DIAGNOSIS; PRESSURE; GENOMICS; OUTCOMES;

D O I：

10.1016/j.hfc.2014.04.008

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous syndrome, with several underlying etiologic and pathophysiologic factors. The heterogeneity of the HFpEF syndrome may explain why (1) diagnosing and treating HFpEF is so challenging and (2) clinical trials in HFpEF have failed thus far. Here we describe 4 ways of categorizing HFpEF based on pathophysiology, clinical/etiologic subtype, type of clinical presentation, and quantitative phenomics (phenomapping analysis). Regardless of the classification method used, improved phenotypic characterization of HFpEF, and matching targeted therapies with specific HFpEF subtypes, will be a critical step towards improving outcomes in this increasingly prevalent syndrome.

引用

页码：407 / +

页数：14

共 48 条

[1] Prevalence, Clinical Phenotype, and Outcomes Associated With Normal B-Type Natriuretic Peptide Levels in Heart Failure With Preserved Ejection Fraction [J].

Anjan, Venkatesh Y. ;

Loftus, Timothy M. ;

Burke, Michael A. ;

Akhter, Nausheen ;

Fonarow, Gregg C. ;

Gheorghiade, Mihai ;

Shah, Sanjiv J. .

AMERICAN JOURNAL OF CARDIOLOGY, 2012, 110 (06) :870-876

[2] Impact of Noncardiac Comorbidities on Morbidity and Mortality in a Predominantly Male Population With Heart Failure and Preserved Versus Reduced Ejection Fraction [J].

Ather, Sameer ;

Chan, Wenyaw ;

Bozkurt, Biykem ;

Aguilar, David ;

Ramasubbu, Kumudha ;

Zachariah, Amit A. ;

Wehrens, Xander H. T. ;

Deswal, Anita .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2012, 59 (11) :998-1005

[3] Diastolic heart failure [J].

Maurer, MS ;

Packer, M ;

Burkhoff, D .

NEW ENGLAND JOURNAL OF MEDICINE, 2004, 351 (11) :1143-1143

[4] Genetics and genomics - Gene expression microarrays [J].

Ballman, Karla V. .

CIRCULATION, 2008, 118 (15) :1593-1597

[5]

Bench Travis, 2009, Curr Heart Fail Rep, V6, P57

[6] Impaired chronotropic and vasodilator reserves limit exercise capacity in patients with heart failure and a preserved ejection fraction [J].

Borlaug, Barry A. ;

Melenovsky, Vojtech ;

Russell, Stuart D. ;

Kessler, Kristy ;

Pacak, Karel ;

Becker, Lewis C. ;

Kass, David A. .

CIRCULATION, 2006, 114 (20) :2138-2147

[7] Diastolic and Systolic Heart Failure Are Distinct Phenotypes Within the Heart Failure Spectrum [J].

Borlaug, Barry A. ;

Redfield, Margaret M. .

CIRCULATION, 2011, 123 (18) :2006-2013

[8] Heart failure with preserved ejection fraction: pathophysiology, diagnosis, and treatment [J].

Borlaug, Barry A. ;

Paulus, Walter J. .

EUROPEAN HEART JOURNAL, 2011, 32 (06) :670-+

[9] Exercise Hemodynamics Enhance Diagnosis of Early Heart Failure With Preserved Ejection Fraction [J].

Borlaug, Barry A. ;

Nishimura, Rick A. ;

Sorajja, Paul ;

Lam, Carolyn S. P. ;

Redfield, Margaret M. .

CIRCULATION-HEART FAILURE, 2010, 3 (05) :588-+

[10] Diastolic stress echocardiography: Hemodynamic validation and clinical significance of estimation of ventricular filling pressure with exercise [J].

Burgess, MI ;

Jenkins, C ;

Sharman, JE ;

Marwick, TH .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2006, 47 (09) :1891-1900

← 1 2 3 4 5 →