Cytotoxic and COX-2 inhibition properties of hydroxycinnamic derivatives

被引：0
作者：
Marques, M. Paula M.
Borges, Fernanda
Sousa, Joana
Calheiros, Rita
Garrido, Jorge
Gaspar, Alexandra
Antunes, Fernanda
Diniz, Carmen
Fresco, Paula
机构：
[1] Univ Porto, Serv Farmacol, Fac Farm, GEQOFFUP, P-4050047 Oporto, Portugal
[2] Univ Coimbra, Unidade Quim Fis Mol, P-3000 Coimbra, Portugal
[3] Univ Coimbra, Dept Bioquim, Fac Ciencias & Tecnol, P-3000 Coimbra, Portugal
[4] Univ Porto, Serv Quim Organ, Fac Farm, P-4050047 Oporto, Portugal
[5] Inst Politecn Porto, Dept Engn Quim, ISEP, Oporto, Portugal
来源：
LETTERS IN DRUG DESIGN & DISCOVERY | 2006年 / 3卷 / 05期
关键词：
hydroxycinnamic derivatives; anti-inflammatory; COX-2; anticancer; mammary gland adenocarcinoma cells;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The anticancer (cytotoxicity against human mammary gland adenocarcinoma cells) and anti-inflammatory properties (COX-2 inhibition) of the hydroxycinnamic derivatives trans-3-(3,4,5-trihydroxyphenyl)-2-propenoic acid, trans-ethyl(3,4,5-trihydroxyphenyl)-2-propenoate and diethyl 2-(3,4,5-trihydroxy-phenylmethylene)malonate were screened. Data point out a putative correlation between anti-inflammatory and anticancer properties and suggest hydroxycinnamic derivatives as promising lead compounds for the development of anti-inflammatory/chemopreventive agents.
引用
收藏
页码：316 / 320
页数：5
相关论文
共 42 条
  • [21] Michaluart P, 1999, CANCER RES, V59, P2347
  • [22] Selective antiproliferative activity of caffeic acid phenethyl ester analogues on highly liver-metastatic murine colon 26-L5 carcinoma cell line
    Nagaoka, T
    Banskota, AH
    Tezuka, Y
    Saiki, I
    Kadota, S
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY, 2002, 10 (10) : 3351 - 3359
  • [23] Assessment of the Alamar Blue assay for cellular growth and viability in vitro
    Nakayama, GR
    Caton, MC
    Nova, MP
    Parandoosh, Z
    [J]. JOURNAL OF IMMUNOLOGICAL METHODS, 1997, 204 (02) : 205 - 208
  • [24] NAKAYAMA T, 1994, CANCER RES, V54, pS1991
  • [25] Structure-antioxidant activity relationship of ferulic acid derivatives: Effect of carbon side chain characteristic groups
    Nenadis, N
    Zhang, HY
    Tsimidou, MZ
    [J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2003, 51 (07) : 1874 - 1879
  • [26] Suppression of cell transformation and induction of apoptosis by caffeic acid phenethyl ester
    Nomura, M
    Kaji, A
    Ma, W
    Miyamoto, K
    Dong, Z
    [J]. MOLECULAR CARCINOGENESIS, 2001, 31 (02) : 83 - 89
  • [27] Investigation of the Alamar Blue (resazurin) fluorescent dye for the assessment of mammalian cell cytotoxicity
    O'Brien, J
    Wilson, I
    Orton, T
    Pognan, F
    [J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 2000, 267 (17): : 5421 - 5426
  • [28] PARVATANENI R, 2005, BIOL PHARM BULL, V28, P1311
  • [29] COMPARATIVE CYTOTOXICITY OF PHENOLS INVITRO
    PASSI, S
    PICARDO, M
    NAZZAROPORRO, M
    [J]. BIOCHEMICAL JOURNAL, 1987, 245 (02) : 537 - 542
  • [30] The role of NSAIDs in the prevention of colon cancer
    Rayyan, Y
    Williams, J
    Rigas, B
    [J]. CANCER INVESTIGATION, 2002, 20 (7-8) : 1002 - 1011
12345