Cytotoxic and COX-2 inhibition properties of hydroxycinnamic derivatives

被引：0
作者：
Marques, M. Paula M.
Borges, Fernanda
Sousa, Joana
Calheiros, Rita
Garrido, Jorge
Gaspar, Alexandra
Antunes, Fernanda
Diniz, Carmen
Fresco, Paula
机构：
[1] Univ Porto, Serv Farmacol, Fac Farm, GEQOFFUP, P-4050047 Oporto, Portugal
[2] Univ Coimbra, Unidade Quim Fis Mol, P-3000 Coimbra, Portugal
[3] Univ Coimbra, Dept Bioquim, Fac Ciencias & Tecnol, P-3000 Coimbra, Portugal
[4] Univ Porto, Serv Quim Organ, Fac Farm, P-4050047 Oporto, Portugal
[5] Inst Politecn Porto, Dept Engn Quim, ISEP, Oporto, Portugal
来源：
LETTERS IN DRUG DESIGN & DISCOVERY | 2006年 / 3卷 / 05期
关键词：
hydroxycinnamic derivatives; anti-inflammatory; COX-2; anticancer; mammary gland adenocarcinoma cells;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The anticancer (cytotoxicity against human mammary gland adenocarcinoma cells) and anti-inflammatory properties (COX-2 inhibition) of the hydroxycinnamic derivatives trans-3-(3,4,5-trihydroxyphenyl)-2-propenoic acid, trans-ethyl(3,4,5-trihydroxyphenyl)-2-propenoate and diethyl 2-(3,4,5-trihydroxy-phenylmethylene)malonate were screened. Data point out a putative correlation between anti-inflammatory and anticancer properties and suggest hydroxycinnamic derivatives as promising lead compounds for the development of anti-inflammatory/chemopreventive agents.
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页码：316 / 320
页数：5
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