Sex is a stronger predictor of colorectal adenoma and advanced adenoma than fecal occult blood test

被引：18

作者：

Ferlitsch, Monika ^{[1
,2
]}

Heinze, Georg ^{[3
]}

Salzl, Petra ^{[1
,2
]}

Britto-Arias, Martha ^{[1
,2
]}

Waldmann, Elisabeth ^{[1
,2
]}

Reinhart, Karoline ^{[1
,2
]}

Bannert, Christina ^{[1
,2
]}

Fasching, Elisabeth ^{[4
]}

Knoflach, Peter ^{[1
]}

Weiss, Werner ^{[1
]}

Trauner, Michael ^{[1
,2
]}

Ferlitsch, Arnulf ^{[1
,2
]}

机构：

[1] Austrian Soc Gastroenterol & Hepatol, Qual Assurance Working Grp, A-1010 Vienna, Austria

[2] Med Univ Vienna, Div Gastroenterol & Hepatol, A-1090 Vienna, Austria

[3] Med Univ Vienna, Ctr Med Stat Informat & Intelligent Syst, Div Clin Biometr, A-1090 Vienna, Austria

[4] Main Assoc Austrian Social Insurance Inst, Vienna, Austria

来源：

MEDICAL ONCOLOGY | 2014年 / 31卷 / 09期

关键词：

Fecal occult blood test; Screening colonoscopy; Adenoma detection rate; Advanced adenoma detection rate; SCREENING COLONOSCOPY; ADVANCED NEOPLASIA; CANCER; INDIVIDUALS; POPULATION; RISK;

D O I：

10.1007/s12032-014-0151-0

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Due to high costs and limited availability of screening colonoscopy, some screening programs require a positive fecal occult blood test (FOBT) before screening colonoscopy is remunerated. As male sex is a strong predictor of adenoma and advanced adenoma, we evaluated whether a positive FOBT or male sex is a stronger risk factor for adenoma and advanced adenoma. FOBT and screening colonoscopy results from 18.665 consecutive patients participating in a "national health check program'' between 2009 and 2011 were included in this cohort study. Age-corrected adenoma detection rates (ADR), advanced adenoma detection rates (AADR) and carcinoma detection rates were calculated for men and women according to FOBT result separately. ADR and AADR in FOBT-positive men (34.6 and 11.8 %) and FOBT-negative men (29.1 and 7.6 %) were higher than ADR and AADR in FOBT-positive women (20 and 6.9 %) and in FOBT-negative women (17.6 and 4.4 %), (p = 0.0003). Men with negative FOBT were at higher risk of having an adenoma and advanced adenoma than women with positive FOBT (p < 0.0001). Odds ratios of a positive FOBT for ADR and AADR were 1.3 (1.1-1.5) (p = 0.0047) and 1.6 (1.2-2.1) (p < 0.0001), respectively. Odds ratios of male sex to predict ADR and AADR were significantly higher with 1.9 (1.8-2.1) and 1.8 (1.6-2), respectively (p < 0.001). Male sex is a stronger predictor for colorectal adenoma and advanced adenoma than positive FOBT. These results should be taken into account analyzing FOBT-based screening programs.

引用

页码：1 / 7

页数：7

共 20 条

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