Sex is a stronger predictor of colorectal adenoma and advanced adenoma than fecal occult blood test

被引:18
作者
Ferlitsch, Monika [1 ,2 ]
Heinze, Georg [3 ]
Salzl, Petra [1 ,2 ]
Britto-Arias, Martha [1 ,2 ]
Waldmann, Elisabeth [1 ,2 ]
Reinhart, Karoline [1 ,2 ]
Bannert, Christina [1 ,2 ]
Fasching, Elisabeth [4 ]
Knoflach, Peter [1 ]
Weiss, Werner [1 ]
Trauner, Michael [1 ,2 ]
Ferlitsch, Arnulf [1 ,2 ]
机构
[1] Austrian Soc Gastroenterol & Hepatol, Qual Assurance Working Grp, A-1010 Vienna, Austria
[2] Med Univ Vienna, Div Gastroenterol & Hepatol, A-1090 Vienna, Austria
[3] Med Univ Vienna, Ctr Med Stat Informat & Intelligent Syst, Div Clin Biometr, A-1090 Vienna, Austria
[4] Main Assoc Austrian Social Insurance Inst, Vienna, Austria
关键词
Fecal occult blood test; Screening colonoscopy; Adenoma detection rate; Advanced adenoma detection rate; SCREENING COLONOSCOPY; ADVANCED NEOPLASIA; CANCER; INDIVIDUALS; POPULATION; RISK;
D O I
10.1007/s12032-014-0151-0
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Due to high costs and limited availability of screening colonoscopy, some screening programs require a positive fecal occult blood test (FOBT) before screening colonoscopy is remunerated. As male sex is a strong predictor of adenoma and advanced adenoma, we evaluated whether a positive FOBT or male sex is a stronger risk factor for adenoma and advanced adenoma. FOBT and screening colonoscopy results from 18.665 consecutive patients participating in a "national health check program'' between 2009 and 2011 were included in this cohort study. Age-corrected adenoma detection rates (ADR), advanced adenoma detection rates (AADR) and carcinoma detection rates were calculated for men and women according to FOBT result separately. ADR and AADR in FOBT-positive men (34.6 and 11.8 %) and FOBT-negative men (29.1 and 7.6 %) were higher than ADR and AADR in FOBT-positive women (20 and 6.9 %) and in FOBT-negative women (17.6 and 4.4 %), (p = 0.0003). Men with negative FOBT were at higher risk of having an adenoma and advanced adenoma than women with positive FOBT (p < 0.0001). Odds ratios of a positive FOBT for ADR and AADR were 1.3 (1.1-1.5) (p = 0.0047) and 1.6 (1.2-2.1) (p < 0.0001), respectively. Odds ratios of male sex to predict ADR and AADR were significantly higher with 1.9 (1.8-2.1) and 1.8 (1.6-2), respectively (p < 0.001). Male sex is a stronger predictor for colorectal adenoma and advanced adenoma than positive FOBT. These results should be taken into account analyzing FOBT-based screening programs.
引用
收藏
页码:1 / 7
页数:7
相关论文
共 20 条
[1]  
Ambler GBA, 2010, MFP PACKAGE
[2]   Sex-Specific Prevalence of Adenomas, Advanced Adenomas, and Colorectal Cancer in Individuals Undergoing Screening Colonoscopy [J].
Ferlitsch, Monika ;
Reinhart, Karoline ;
Pramhas, Sibylle ;
Wiener, Caspar ;
Gal, Orsolya ;
Bannert, Christina ;
Hassler, Michaela ;
Kozbial, Karin ;
Dunkler, Daniela ;
Trauner, Michael ;
Weiss, Werner .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2011, 306 (12) :1352-1358
[3]   The first 3 years of national bowel cancer screening at a single UK tertiary centre [J].
Gupta, S. ;
Saunders, B. P. ;
Fraser, C. ;
Kennedy, R. H. ;
Ignjatovic, A. ;
Sala, S. ;
Marshall, S. ;
Suzuki, N. ;
Vance, M. ;
Thomas-Gibson, S. .
COLORECTAL DISEASE, 2012, 14 (02) :166-173
[4]   Systematic review: distribution of advanced neoplasia according to polyp size at screening colonoscopy [J].
Hassan, C. ;
Pickhardt, P. J. ;
Kim, D. H. ;
Di Giulio, E. ;
Zullo, A. ;
Laghi, A. ;
Repici, A. ;
Iafrate, F. ;
Osborn, J. ;
Annibale, B. .
ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2010, 31 (02) :210-217
[5]   Sensitivity of immunochemical faecal occult blood testing for detecting left- vs right-sided colorectal neoplasia [J].
Haug, U. ;
Kuntz, K. M. ;
Knudsen, A. B. ;
Hundt, S. ;
Brenner, H. .
BRITISH JOURNAL OF CANCER, 2011, 104 (11) :1779-1785
[6]   Quantitative Immunochemical Fecal Occult Blood Testing for Colorectal Adenoma Detection: Evaluation in the Target Population of Screening and Comparison With Qualitative Tests [J].
Haug, Ulrike ;
Hundt, Sabrina ;
Brenner, Hermann .
AMERICAN JOURNAL OF GASTROENTEROLOGY, 2010, 105 (03) :682-690
[7]   Male Sex and Smoking Have a Larger Impact on the Prevalence of Colorectal Neoplasia Than Family History of Colorectal Cancer [J].
Hoffmeister, Michael ;
Schmitz, Stephanie ;
Karmrodt, Elisabeth ;
Stegmaier, Christa ;
Haug, Ulrike ;
Arndt, Volker ;
Brenner, Hermann .
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2010, 8 (10) :870-876
[8]   Comparative Evaluation of Immunochemical Fecal Occult Blood Tests for Colorectal Adenoma Detection [J].
Hundt, Sabrina ;
Haug, Ulrike ;
Brenner, Hermann .
ANNALS OF INTERNAL MEDICINE, 2009, 150 (03) :162-+
[9]   Colorectal Cancer Screening by Primary Care Physicians Recommendations and Practices, 2006-2007 [J].
Klabunde, Carrie N. ;
Lanier, David ;
Nadel, Marion R. ;
McLeod, Caroline ;
Yuan, Gigi ;
Vernon, Sally W. .
AMERICAN JOURNAL OF PREVENTIVE MEDICINE, 2009, 37 (01) :8-16
[10]   Risk of Advanced Colorectal Neoplasia According to Age and Gender [J].
Kolligs, Frank T. ;
Crispin, Alexander ;
Munte, Axel ;
Wagner, Andreas ;
Mansmann, Ulrich ;
Goeke, Burkhard .
PLOS ONE, 2011, 6 (05)