Stabilized Helical Peptides: A Strategy to Target Protein-Protein Interactions

被引：14
|
作者：
Klein, Mark A. [1 ,2 ]
机构：
[1] Minneapolis VA Hlth Care Syst, Minneapolis, MN 55417 USA
[2] Univ Minnesota, Div Hematol Oncol & Transplantat, Dept Med, Minneapolis, MN 55455 USA
来源：
ACS MEDICINAL CHEMISTRY LETTERS | 2014年 / 5卷 / 08期
关键词：
stabilized peptide; alpha helix; protein-protein interactions; MIMICRY;
D O I：
10.1021/ml500235d
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Protein-protein interactions are critical for cell proliferation, differentiation, and function. Peptides hold great promise for clinical applications focused on targeting protein-protein interactions. Advantages of peptides include a large chemical space and potential diversity of sequences and structures. However, peptides do present well-known challenges for drug development. Progress has been made in the development of stabilizing alpha helices for potential therapeutic applications. Advantages and disadvantages of different methods of helical peptide stabilization are discussed.
引用
收藏
页码：838 / 839
页数：2
相关论文
共 50 条
  • [1] Peptides that target protein-protein interactions as an anti-parasite strategy
    Qvit, Nir
    Crapster, J. Aaron
    CHIMICA OGGI-CHEMISTRY TODAY, 2014, 32 (06) : 31 - 36
  • [2] CYCLIC PEPTIDES FOR TARGETING HELICAL PROTEIN-PROTEIN INTERACTIONS
    Neukirchen, S.
    Roschger, C.
    Elsaesser, B.
    Schubert, M.
    Cabrele, C.
    JOURNAL OF PEPTIDE SCIENCE, 2016, 22 : S50 - S52
  • [3] Stretching Peptides' Potential to Target Protein-Protein Interactions
    Venneti, Naresh M.
    Stockdill, Jennifer L.
    ACS CENTRAL SCIENCE, 2023, 9 (04) : 590 - 592
  • [4] Transmembrane Peptides as Inhibitors of Protein-Protein Interactions: An Efficient Strategy to Target Cancer Cells?
    Albrecht, Camille
    Appert-Collin, Aline
    Bagnard, Dominique
    Blaise, Sebastien
    Romier-Crouzet, Beatrice
    Efremov, Roman G.
    Sartelet, Herve
    Duca, Laurent
    Maurice, Pascal
    Bennasroune, Amar
    FRONTIERS IN ONCOLOGY, 2020, 10
  • [5] Constrained α-Helical Peptides as Inhibitors of Protein-Protein and Protein-DNA Interactions
    Roy, Siddhartha
    Ghosh, Piya
    Ahmed, Israr
    Chakraborty, Madhumita
    Naiya, Gitashri
    Ghosh, Basusree
    BIOMEDICINES, 2018, 6 (04)
  • [6] Guanidinium-Stapled Helical Peptides for Targeting Protein-Protein Interactions
    Perdriau, Camille
    Luton, Anais
    Zimmeter, Katharina
    Neuville, Maxime
    Saragaglia, Claire
    Peluso-Iltis, Carole
    Osz, Judit
    Kauffmann, Brice
    Collie, Gavin W.
    Rochel, Natacha
    Guichard, Gilles
    Pasco, Morgane
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2025, 64 (05)
  • [7] Utilization of macrocyclic peptides to target protein-protein interactions in cancer
    Yang, Jiawen
    Zhu, Qiaoliang
    Wu, Yifan
    Qu, Xiaojuan
    Liu, Haixia
    Jiang, Biao
    Ge, Di
    Song, Xiaoling
    FRONTIERS IN ONCOLOGY, 2022, 12
  • [8] Protein-protein interactions and functional peptides
    Legrain, P
    REGULATORY PEPTIDES, 2004, 122 (01) : 3 - 3
  • [9] β-Peptides as inhibitors of protein-protein interactions
    Kritzer, JA
    Stephens, OM
    Guarracino, DA
    Reznik, SK
    Schepartz, A
    BIOORGANIC & MEDICINAL CHEMISTRY, 2005, 13 (01) : 11 - 16
  • [10] Assessment of helical interfaces in protein-protein interactions
    Jochim, Andrea L.
    Arora, Paramjit S.
    MOLECULAR BIOSYSTEMS, 2009, 5 (09) : 924 - 926
12345