A new lariciresinol-type butyrolactone lignan derived from hydroxymatairesinol and its identification in spruce wood

被引：22

作者：

Eklund, PC

Willför, SM

Smeds, AI

Sundell, FJ

Sjöholm, RE

Holmbom, BR

机构：

[1] Abo Akad Univ, Proc Chem Ctr, Dept Organ Chem, FIN-20500 Turku, Finland

[2] Abo Akad Univ, Proc Chem Ctr, Lab Wood & Paper Chem, FIN-20500 Turku, Finland

来源：

JOURNAL OF NATURAL PRODUCTS | 2004年 / 67卷 / 06期

关键词：

D O I：

10.1021/np0340706

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

When the natural lignan hydroxymatairesinol (1) was treated with an alkaline aqueous solution, it partially rearranged to isomeric forms of a lariciresinol-type butyrolactone lignan. The two major diastereomers formed (2 and 3) were isolated by column and medium-pressure chromatography, and their structures were elucidated by MS and NMR techniques. These previously unknown butyrolactone lignans were identified as naturally occurring in spruce knotwood by GC, GC-MS, and HPLC-ESI MS/MS analyses. The formation of isohydroxymatairesinol (2) and epi-isohydroxymatairesinol (3) from hydroxymatairesinol (1), and their detection in rat urine after administration of 1, is discussed.

引用

页码：927 / 931

页数：5

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