Effect of Preexisting Serum and Mucosal Antibody on Experimental Respiratory Syncytial Virus (RSV) Challenge and Infection of Adults

被引：71

作者：

Bagga, Bindiya ^{[1
,2
,3
]}

Cehelsky, Jeffrey E. ^{[4
]}

Vaishnaw, Akshay ^{[4
]}

Wilkinson, Tom ^{[5
]}

Meyers, Rachel ^{[4
]}

Harrison, Lisa M. ^{[1
]}

Roddam, Philippa L. ^{[1
,2
,3
]}

Walsh, Edward E. ^{[6
,7
]}

DeVincenzo, John P. ^{[1
,2
,3
,8
]}

机构：

[1] Univ Tennessee, Hlth Sci Ctr, Dept Pediat, Memphis, TN 38103 USA

[2] Le Bonheur Childrens Hosp, Memphis, TN USA

[3] Childrens Fdn Res Inst, Memphis, TN USA

[4] Alnylam Pharmaceut, Cambridge, MA USA

[5] Univ Southampton, Fac Med, Clin & Expt Sci, Southampton SO9 5NH, Hants, England

[6] Univ Rochester, Sch Med & Dent, New York, NY USA

[7] Rochester Gen Hosp, New York, NY USA

[8] Univ Tennessee, Ctr Hlth Sci, Dept Mol Sci, Memphis, TN 38103 USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2015年 / 212卷 / 11期

关键词：

respiratory syncytial virus; vaccines; serum antibody responses; mucosal antibody responses; correlates of protection; VIRAL LOAD; INFLUENZA; VACCINE; PROTECTION; IMMUNITY; INFANTS; DISEASE; HUMANS; RISK;

D O I：

10.1093/infdis/jiv281

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We studied preexisting respiratory syncytial virus (RSV)specific serum and nasal antibodies and their correlation with infectivity, viral dynamics, and disease severity in a human experimental infection model. Higher preinoculation serum neutralizing antibody titers and nasal immunoglobulin (Ig) A predicted lower infectivity and lower measures of viral replication. However, once individuals were infected, no significant protective effect of preexisting antibodies was seen. Lack of correlation between serum and mucosal antibodies was observed, implying that they are independent co-correlates of protection against RSV infection. We suggest that protection from RSV infection is a function of a complex interplay between mucosal and serum humoral immune responses.

引用

页码：1719 / 1725

页数：7

共 15 条

[1] Localized Mucosal Response to Intranasal Live Attenuated Influenza Vaccine in Adults [J].

Barria, Maria Ines ;

Garrido, Jose Luis ;

Stein, Cheryl ;

Scher, Erica ;

Ge, Yongchao ;

Engel, Stephanie M. ;

Kraus, Thomas A. ;

Banach, David ;

Moran, Thomas M. .

JOURNAL OF INFECTIOUS DISEASES, 2013, 207 (01) :115-124

[2] Viral Load Drives Disease in Humans Experimentally Infected with Respiratory Syncytial Virus [J].

DeVincenzo, John P. ;

Wilkinson, Tom ;

Vaishnaw, Akshay ;

Cehelsky, Jeff ;

Meyers, Rachel ;

Nochur, Saraswathy ;

Harrison, Lisa ;

Meeking, Patricia ;

Mann, Alex ;

Moane, Elizabeth ;

Oxford, John ;

Pareek, Rajat ;

Moore, Ryves ;

Walsh, Ed ;

Studholme, Robert ;

Dorsett, Preston ;

Alvarez, Rene ;

Lambkin-Williams, Robert .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2010, 182 (10) :1305-1314

[3] Natural infection of infants with respiratory syncytial virus subgroups A and B: A study of frequency, disease severity, and viral load [J].

DeVincenzo, JP .

PEDIATRIC RESEARCH, 2004, 56 (06) :914-917

[4] Serum antibody decay in adults following natural respiratory syncytial virus infection [J].

Falsey, Ann R. ;

Singh, Harjot K. ;

Walsh, Edward E. .

JOURNAL OF MEDICAL VIROLOGY, 2006, 78 (11) :1493-1497

[5] Relationship of serum antibody to risk of respiratory syncytial virus infection in elderly adults [J].

Falsey, AR ;

Walsh, EE .

JOURNAL OF INFECTIOUS DISEASES, 1998, 177 (02) :463-466

[6] Respiratory Syncytial Virus Human Experimental Infection Model: Provenance, Production, and Sequence of Low-Passaged Memphis-37 Challenge Virus [J].

Kim, Young-In ;

DeVincenzo, John P. ;

Jones, Bart G. ;

Rudraraju, Rajeev ;

Harrison, Lisa ;

Meyers, Rachel ;

Cehelsky, Jeff ;

Alvarez, Rene ;

Hurwitz, Julia L. .

PLOS ONE, 2014, 9 (11)

[7] Experimental infection of humans with A2 respiratory syncytial virus [J].

Lee, FEH ;

Walsh, EE ;

Falsey, AR ;

Betts, RE ;

Treanor, JJ .

ANTIVIRAL RESEARCH, 2004, 63 (03) :191-196

[8] Reduction of respiratory syncytial virus (RSV) in tracheal aspirates in intubated infants by use of humanized monoclonal antibody to RSV F protein [J].

Malley, R ;

DeVincenzo, J ;

Ramilo, O ;

Dennehy, PH ;

Meissner, HC ;

Gruber, WC ;

Sanchez, PJ ;

Jafri, H ;

Balsley, J ;

Carlin, D ;

Buckingham, S ;

Vernacchio, L ;

Ambrosino, DM .

JOURNAL OF INFECTIOUS DISEASES, 1998, 178 (06) :1555-1561

[9] Correlates of vaccine protection from influenza and its complications [J].

McCullers, Jonathan A. ;

Huber, Victor C. .

HUMAN VACCINES & IMMUNOTHERAPEUTICS, 2012, 8 (01) :34-44

[10]

MILLS J, 1971, J IMMUNOL, V107, P123

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