Anti-tumour and immunomodulatory activities of oligosaccharides isolated from Panax ginseng CA Meyer

被引：50
作者：
Jiao, Lili [1 ]
Zhang, Xiaoyu [1 ]
Li, Bo [1 ]
Liu, Zhen [1 ]
Wang, Mingzhu [1 ]
Liu, Shuying [1 ,2 ]
机构：
[1] Jilin Ginseng Acad, Changchun Univ Chinese Med, Changchun 130117, Jilin Province, Peoples R China
[2] Chinese Acad Sci, Changchun Inst Appl Chem, Changchun 130022, Peoples R China
来源：
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2014年 / 65卷
关键词：
Panax ginseng; Oligosaccharides; Anti-tumour; Immunomodulatory; MACROPHAGES; CELLS;
D O I：
10.1016/j.ijbiomac.2014.01.039
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Water-soluble ginseng oligosaccharides (WGOS) composed of D-glucose with a degree of polymerisation ranging from 2 to 14 were obtained from Panax ginseng C.A. Meyer. In this study, the anti-tumour and immunoregulatory effects of WGOS were evaluated in Hepatoma-22 (H22)-bearing mice. Treatment with WGOS inhibited tumour growth in vivo and significantly increased relative spleen and thymus weight, serum tumour necrosis factor-alpha level, spleen lymphocyte proliferation, natural killer cell activity, phagocytic function and nitric oxide production secreted by macrophage in H22-bearing mice. However, no direct cytotoxicity was detected. Therefore, the anti-tumour activity of WGOS may be related to their immunomodulatory effects. (c) 2014 Elsevier B.V. All rights reserved.
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收藏
页码：229 / 233
页数：5
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