Stem Cells-A Source of Adult Red Blood Cells for Transfusion Purposes: Present and Future

被引：20
|
作者：
Douay, Luc [1 ,2 ,3 ]
Lapillonne, Helene [1 ,2 ,3 ]
Turhan, Ali G. [4 ]
机构：
[1] Hop Armand Trousseau, AP HP, Serv Hematol Biol, F-75012 Paris, France
[2] INSERM, UMR S 893, F-75005 Paris, France
[3] Univ Paris 06, UMR S 893, F-75005 Paris, France
[4] Univ Poitiers, UPRES EA 3805, Div Lab Hematol & Oncol, F-86021 Poitiers, France
来源：
CRITICAL CARE CLINICS | 2009年 / 25卷 / 02期
关键词：
Red blood cell; Transfusion; Enucleation; Hemoglobin; Hematopoietic stem cells; ES cells; IPS; EX-VIVO EXPANSION; HEMATOPOIETIC PROGENITORS; DIFFERENTIATION CULTURES; DEFINED FACTORS; CORD BLOOD; FIBROBLASTS; MARROW; GLOBIN; STROMA; PROLIFERATION;
D O I：
10.1016/j.ccc.2008.12.008
中图分类号：
R4 [临床医学];
学科分类号：
1002 ; 100602 ;
摘要：
We have sufficient knowledge of the biology of hematopoietic stem cells to hope that we might generate human red blood cells in the laboratory. It may soon be possible to produce enough to transfuse "cultured" red blood cells to manufacture human red blood cells from hematopoietic stem cells for transfusion purposes. This article describes progress and the challenges that remain in the search for in vitro generated red blood cells that can be efficiently manufactured in high volumes and given to any recipient.
引用
收藏
页码：383 / +
页数：17
相关论文
共 50 条
  • [21] The path from stem cells to red blood cells
    Hideo Harigae
    International Journal of Hematology, 2022, 116 : 160 - 162
  • [22] Adult Stem Cells as an Alternative Source of Multipotential (Pluripotential) Cells in Regenerative Medicine
    Kuci, Selim
    Kuci, Zyrafete
    Latifi-Pupovci, Hatixhe
    Niethammer, Dietrich
    Handgretinger, Rupert
    Schumm, Michael
    Bruchelt, Gernot
    Bader, Peter
    Klingebiel, Thomas
    CURRENT STEM CELL RESEARCH & THERAPY, 2009, 4 (02) : 107 - 117
  • [23] Adult bone marrow is a rich source of human mesenchymal 'stem' cells but umbilical cord and mobilized adult blood are not
    Wexler, SA
    Donaldson, C
    Denning-Kendall, P
    Rice, C
    Bradley, B
    Hows, JM
    BRITISH JOURNAL OF HAEMATOLOGY, 2003, 121 (02) : 368 - 374
  • [24] Stem cells in nephrology: present status and future
    Ewa Wątorek
    Marian Klinger
    Archivum Immunologiae et Therapiae Experimentalis, 2006, 54 : 45 - 50
  • [25] Stem cells in nephrology: present status and future
    Watorek, E
    Klinger, M
    ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS, 2006, 54 (01) : 45 - 50
  • [26] Effect of donor and red blood cells concentrate characteristics on recipient hemoglobin increment following red blood cells transfusion in pediatric patients
    Saqlain, Nazish
    Mazher, Naghmana
    Arshad, Sundas
    Sajjal, Maha
    PAKISTAN JOURNAL OF MEDICAL SCIENCES, 2022, 38 (06) : 1420 - 1425
  • [27] Evaluation of Stem Cell-Derived Red Blood Cells as a Transfusion Product Using a Novel Animal Model
    Shah, Sandeep N.
    Gelderman, Monique P.
    Lewis, Emily M. A.
    Farrel, John
    Wood, Francine
    Strader, Michael Brad
    Alayash, Abdu I.
    Vostal, Jaroslav G.
    PLOS ONE, 2016, 11 (12):
  • [28] Immunologic profiles of red blood cells using in vitro models of transfusion
    Long, Kristin
    Meier, Cindy
    Ward, Martin
    Williams, Dennis
    Woodward, Jerold
    Bernard, Andrew
    JOURNAL OF SURGICAL RESEARCH, 2013, 184 (01) : 567 - 571
  • [29] In vitro generation of red blood cells for transfusion: a model for regenerative medicine
    Douay, Luc
    REGENERATIVE MEDICINE, 2012, 7 (01) : 1 - 2
  • [30] Proof of principle for transfusion of in vitro-generated red blood cells
    Giarratana, Marie-Catherine
    Rouard, Helene
    Dumont, Agnes
    Kiger, Laurent
    Safeukui, Innocent
    Le Pennec, Pierre-Yves
    Francois, Sabine
    Trugnan, Germain
    Peyrard, Thierry
    Marie, Tiffany
    Jolly, Severine
    Hebert, Nicolas
    Mazurier, Christelle
    Mario, Nathalie
    Harmand, Laurence
    Lapillonne, Helene
    Devaux, Jean-Yves
    Douay, Luc
    BLOOD, 2011, 118 (19) : 5071 - 5079
12345