Stem Cells-A Source of Adult Red Blood Cells for Transfusion Purposes: Present and Future

被引：20

作者：

Douay, Luc ^{[1
,2
,3
]}

Lapillonne, Helene ^{[1
,2
,3
]}

Turhan, Ali G. ^{[4
]}

机构：

[1] Hop Armand Trousseau, AP HP, Serv Hematol Biol, F-75012 Paris, France

[2] INSERM, UMR S 893, F-75005 Paris, France

[3] Univ Paris 06, UMR S 893, F-75005 Paris, France

[4] Univ Poitiers, UPRES EA 3805, Div Lab Hematol & Oncol, F-86021 Poitiers, France

来源：

CRITICAL CARE CLINICS | 2009年 / 25卷 / 02期

关键词：

Red blood cell; Transfusion; Enucleation; Hemoglobin; Hematopoietic stem cells; ES cells; IPS; EX-VIVO EXPANSION; HEMATOPOIETIC PROGENITORS; DIFFERENTIATION CULTURES; DEFINED FACTORS; CORD BLOOD; FIBROBLASTS; MARROW; GLOBIN; STROMA; PROLIFERATION;

D O I：

10.1016/j.ccc.2008.12.008

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

We have sufficient knowledge of the biology of hematopoietic stem cells to hope that we might generate human red blood cells in the laboratory. It may soon be possible to produce enough to transfuse "cultured" red blood cells to manufacture human red blood cells from hematopoietic stem cells for transfusion purposes. This article describes progress and the challenges that remain in the search for in vitro generated red blood cells that can be efficiently manufactured in high volumes and given to any recipient.

引用

页码：383 / +

页数：17

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