One-step procedure for enhancing the antibacterial and antioxidant properties of a polysaccharide polymer: Kojic acid grafted onto chitosan

被引：37
作者：
Liu, Xiaoli [1 ]
Jiang, Qixing [1 ]
Xia, Wenshui [1 ]
机构：
[1] Iangnan Univ, Collaborat Innovat Ctr Food Safety & Qual Control, Sch Food Sci & Technol, State Key Lab Food Sci & Technol, Lihu Rd 1800, Wuxi 214122, Jiangsu, Peoples R China
来源：
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2018年 / 113卷
基金：
中国国家自然科学基金; 中国博士后科学基金;
关键词：
Chitosan oligosaccharide; Kojic acid; Bioactivity; ANTIMICROBIAL ACTIVITY; CARBOXYMETHYL CHITOSAN; STAPHYLOCOCCUS-AUREUS; COPPER NANOPARTICLES; ESCHERICHIA-COLI; AGENT; OLIGOSACCHARIDE; DERIVATIVES; CHITOOLIGOSACCHARIDES; NANOMICELLES;
D O I：
10.1016/j.ijbiomac.2018.03.007
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The purpose of this work was to develop a nontoxic bioactive material based on a natural pyrone compound (kojic acid, KA) and chitosan oligosaccharides (COS). The bioactive material, chitosan oligosaccharide-N-kojic acid polymer (COS-N-KA), was prepared by one-step environmentally friendly approach. Then, the physicochemical properties and biological activities of COS-N-KA as a prepared water-soluble COS derivative were evaluated. The polymer was characterized by using UV-vis, FTIR, H-1 NMR, and C-13 NMR spectroscopy, Mw, PID, TGA, water solubility, hemolysis assay, and animal toxicity studies. Particularly, the antioxidant and antimicrobial assays revealed that COS-N-KA significantly enhanced the antimicrobial and antioxidant activities, which remarkably stronger than that of free COS and KA. Hence, the low hemolytic activity to human red blood cells, and nontoxic to female mice of SLAC KM strain made this novel polymer material a promising and effective compound for food and pharmaceutical industries. (C) 2018 Elsevier B.V. All rights reserved.
引用
收藏
页码：1125 / 1133
页数：9
相关论文
共 53 条
[11]   Biodegradable Kojic Acid-Based Polymers: Controlled Delivery of Bioactives for Melanogenesis Inhibition [J].
Faig, Jonathan J. ;
Moretti, Alysha ;
Joseph, Laurie B. ;
Zhang, Yingyue ;
Nova, Mary Joy ;
Smith, Kervin ;
Uhrich, Kathryn E. .
BIOMACROMOLECULES, 2017, 18 (02) :363-373
[12]   Characterization and antioxidant activity of β-carotene loaded chitosan-graft-poly(lactide) nanomicelles [J].
Ge, Wenjiao ;
Li, Dong ;
Chen, Meiwan ;
Wang, Xiaohui ;
Liu, Shijie ;
Sun, Runcang .
CARBOHYDRATE POLYMERS, 2015, 117 :169-176
[13]   Chitosan-Thioglycolic Acid as a Versatile Antimicrobial Agent [J].
Geisberger, Georg ;
Gyenge, Emina Besic ;
Hinger, Doris ;
Kaech, Andres ;
Maake, Caroline ;
Patzke, Greta R. .
BIOMACROMOLECULES, 2013, 14 (04) :1010-1017
[14]   Evaluation of antibacterial activity of N-phosphonium chitosan as a novel polymeric antibacterial agent [J].
Guo, Aijie ;
Wang, Feihu ;
Lin, Wentao ;
Xu, Xiaofen ;
Tang, Tingting ;
Shen, Yuanyuan ;
Guo, Shengrong .
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2014, 67 :163-171
[15]   Conformers of Kojic Acid and Their Near-IR-Induced Conversions: Long-Range Intramolecular Vibrational Energy Transfer [J].
Halasa, Anna ;
Reva, Igor ;
Lapinski, Leszek ;
Rostkowska, Hanna ;
Fausto, Rui ;
Nowak, Maciej J. .
JOURNAL OF PHYSICAL CHEMISTRY A, 2016, 120 (17) :2647-2656
[16]   Cyanoethylated Carboxymethyl Chitosan as Water Soluble Binder with Enhanced Adhesion Capability and electrochemical performances for LiFePO4 Cathode [J].
He, Jiarong ;
Wang, Jinglun ;
Zhong, Haoxiang ;
Ding, Jianning ;
Zhang, Lingzhi .
ELECTROCHIMICA ACTA, 2015, 182 :900-907
[17]   Antibacterial activity evaluation of quaternary chitin against Escherichia coli and Staphylococcus aureus [J].
Huang, Jianying ;
Jiang, Hengjun ;
Qiu, Miao ;
Geng, Xiaodong ;
Yang, Ronghua ;
Li, Jianrong ;
Zhang, Chaohua .
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2013, 52 :85-91
[18]   Preparation of copper nanoparticles coated cellulose films with antibacterial properties through one-step reduction [J].
Jia, Baoquan ;
Mei, Yan ;
Cheng, Li ;
Zhou, Jinping ;
Zhang, Lina .
ACS APPLIED MATERIALS & INTERFACES, 2012, 4 (06) :2897-2902
[19]   Chitosan-Iron Oxide Coated Graphene Oxide Nanocomposite Hydrogel: A Robust and Soft Antimicrobial Biofilm [J].
Konwar, Achyut ;
Kalita, Sanjeeb ;
Kotoky, Jibon ;
Chowdhury, Devasish .
ACS APPLIED MATERIALS & INTERFACES, 2016, 8 (32) :20625-20634
[20]   Carboxymethylpullulan Grafted with Aminoguaiacol: Synthesis, Characterization, and Assessment of Antibacterial and Antioxidant Properties [J].
Kouassi, Marie-Carole ;
Thebault, Pascal ;
Rihouey, Christophe ;
De, Emmanuelle ;
Labat, Beatrice ;
Picton, Luc ;
Dulong, Virginie .
BIOMACROMOLECULES, 2017, 18 (10) :3238-3251
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