Fc Gamma Receptor 3B (FCGR3B-c.233C>A-rs5030738) Polymorphism Modifies the Protective Effect of Malaria Specific Antibodies in Ghanaian Children

被引：25
作者：
Adu, Bright [1 ]
Jepsen, Micha Phill Gronholm [1 ]
Gerds, Thomas A. [2 ]
Kyei-Baafour, Eric [3 ]
Christiansen, Michael [1 ]
Dodoo, Daniel [3 ]
Theisen, Michael [1 ]
机构：
[1] Statens Serum Inst, Dept Clin Biochem & Immunol, DK-2300 Copenhagen S, Denmark
[2] Univ Copenhagen, Dept Biostat, DK-1168 Copenhagen, Denmark
[3] Univ Ghana, Noguchi Mem Inst Med Res, Legon, Ghana
来源：
JOURNAL OF INFECTIOUS DISEASES | 2014年 / 209卷 / 02期
关键词：
malaria; GLURP; FCGR3B-c; 233C > A; Fc gamma RIIIB; Plasmodium falciparum; effect modification; neutrophils; GLUTAMATE-RICH PROTEIN; FALCIPARUM-MALARIA; CLINICAL MALARIA; RESPONSES; ANTIGENS;
D O I：
10.1093/infdis/jit422
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Immunoglobulin G (IgG) cross-linking with Fc gamma receptor IIIB (Fc gamma RIIIB) triggers neutrophil degranulation, releasing reactive oxygen species with high levels associated with protection against malaria. The FCGR3B-c.233C > A polymorphism thought to influence the interaction between IgG and Fc gamma RIIIB was recently associated with malaria. We studied the statistical interaction between glutamate rich protein antibodies and FCGR3B-c.233C > A genotypes on risk of malaria in a cohort of Ghanaian children. The absolute risk of malaria decreased more rapidly with increasing antibody levels for 233AA/AC individuals compared with 233CC children. This genotype related effect modification may significantly influence malaria sero-epidemiological and vaccine trial studies.
引用
收藏
页码：285 / 289
页数：5
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